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Insulin resistance, t3, GLUT4, dawn phenomenon
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<blockquote data-quote="AndBreathe" data-source="post: 2491369" data-attributes="member: 88961"><p>Dandelade, it's excellent to hear you are optimally medicated for your thyroid. It must be a relief for you.</p><p></p><p>The thyroid plays a key part of controlling our whole metabolic proccess, so it is not inconceivable insulin resistance could improve. I can't say I noticed anything dramatic myself, but that means nothing.</p><p></p><p>In your post, you say, "...."so had the same breakfast the next day but before my pills and up of 8.5 taking 3 hours to come back down....."</p><p></p><p>How long was it between taking your levothyroxine and eating breakfast or drinking anything containing milk? That can make a difference.</p><p></p><p>Again, apologise for the snippet of your post, but it's easier than trying to pinpoint it in words:</p><p></p><p>You say, "...." that suggest t3 is needed to activate the glucose transporters in cell membranes...." Yes, T3 is key critical.</p><p></p><p>T4 (as is in your Levothyroxine) is a passive hormone. That alone will not do much for you. It is only when your body converts it to T3 that the magic happens. So, if your thyroid gland is just not generating enough T4, but your bdy can still convert it to T3, once adequately titrated you will likely feel better.</p><p></p><p>If, however, your body is unable to convert T4 to T3 at all (or is very inefficient in it's conversion) then the individual will either end up taking very large doses of T4, or require T3 in tablet for, just like the T4. Some folks end up on dual therapy and other just take T3.</p><p></p><p>That said, none of that seems to be an issue for you, if you have achieved optimal levels taking T4 only. That's excellent news!</p></blockquote><p></p>
[QUOTE="AndBreathe, post: 2491369, member: 88961"] Dandelade, it's excellent to hear you are optimally medicated for your thyroid. It must be a relief for you. The thyroid plays a key part of controlling our whole metabolic proccess, so it is not inconceivable insulin resistance could improve. I can't say I noticed anything dramatic myself, but that means nothing. In your post, you say, "...."so had the same breakfast the next day but before my pills and up of 8.5 taking 3 hours to come back down....." How long was it between taking your levothyroxine and eating breakfast or drinking anything containing milk? That can make a difference. Again, apologise for the snippet of your post, but it's easier than trying to pinpoint it in words: You say, "...." that suggest t3 is needed to activate the glucose transporters in cell membranes...." Yes, T3 is key critical. T4 (as is in your Levothyroxine) is a passive hormone. That alone will not do much for you. It is only when your body converts it to T3 that the magic happens. So, if your thyroid gland is just not generating enough T4, but your bdy can still convert it to T3, once adequately titrated you will likely feel better. If, however, your body is unable to convert T4 to T3 at all (or is very inefficient in it's conversion) then the individual will either end up taking very large doses of T4, or require T3 in tablet for, just like the T4. Some folks end up on dual therapy and other just take T3. That said, none of that seems to be an issue for you, if you have achieved optimal levels taking T4 only. That's excellent news! [/QUOTE]
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