Pancreas's exocrine function owes part of its immaculate function to bio-feedback mechanisms controlling secretion of its juice. The following significant pancreatic bio-feedback mechanisms are essential to the maintenance of pancreatic juice balance/production:[3]
- Secretin, a hormone produced by the duodenal "S cells" in response to the stomach chyme containing high hydrogen atom concentration (high acidicity), is released into the blood stream; upon return to the digestive tract, secretion decreases gastric emptying, increases secretion of the pancreatic ductal cells, as well as stimulating pancreatic acinar cells to release their zymogenic juice.
- Cholecystokinin (CCK) is a unique peptide released by the duodenal "I cells" in response to chyme containing high fat or protein content. Unlike secretin, which is an endocrine hormone, CCK actually works via stimulation of a neuronal circuit, the end-result of which is stimulation of the acinar cells to release their content. CCK also increases gallbladder contraction, resulting in bile squeezed into the cystic duct, common bile duct and eventually the duodenum. Bile of course helps absorption of the fat by emulsifying it, increasing its absorptive surface. Bile is made by the liver, but is stored in the gallbladder.
- Gastric inhibitory peptide (GIP) is produced by the mucosal duodenal cells in response to chyme containing high amounts of carbohydrate, proteins, and fatty acids. Main function of GIP is to decrease gastric emptying.
- Somatostatin is a hormone produced by the mucosal cells of the duodenum and also the "delta cells" of the pancreas. Somatostatin has a major inhibitory effect, including on pancreatic juice production.
Steatorrhea. This condition causes your stool to contain an abnormally high level of fat, causing it to take on a yellow color. Those that suffer from celiac disease, inflammation of the pancreas or pancreatitis can develop this condition. If you have steatorrhea food will move too quickly through the digestive system so the body will not be able to absorb the nutrients from the food properly before it is expelled.
lol disturbed - not sure why my brain chose that word in the cold light of day
@AndBreathe this morning my BG level was my normal 5.0 mmol/l So nothing out of the normal there. Oh BTW I remained a couch potato yesterday for the whole day.
I'll have to re-read your findings, regarding digestive pausing to get my head around that concept further. I suppose a counter argument could be that the pancreas, rather than pausing, isn't quite throwing out enough insulin to bring the levels down faster.
Nah just because I was playing the new patch of world of warcraft and then cities in motion. Didnt really feel bloated or anything.And I'm not surprised you were a couch potato yesterday. I wouldn't have been able to move after your lunch!
I pondered this too but then decided that if that was the case then I would not be flat lining at 8 for a period of time and would have just gone high. Now there could be a combination going on here which is reduced pancreatic insulin production along with gastric pausing is retaining my numbers correctly at 8 but the pause is longer than it could be as I am not processing all that glucose fast enough and therefore digestion is taking longer. More experiments required I think.
Now do a thought experiment and extrapolate that to eating like that everyday and I can see how it would edge that HbA1c up just a little until the pre-diabetic levels. Could this be one of the processes that goes wrong?
So I am going to have to do another experiment and add a little exercise in with a huge amount of carby food again. I am pretty sure I have seen this pattern though where the exercise drops it down and then 30 mins later it pops back up
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