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Interesting study about ketones and carbohydrate metabolism
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<blockquote data-quote="Oldvatr" data-source="post: 2434156" data-attributes="member: 196898"><p>I have one problem with the linked article in the OP. Its Reference[21] which he uses as evidence to support the claim that insulin is not required for glucose uptake is actually a report looking into sport use of Growth Hormone, and finding ways to detect this drug abuse in athletes. Now it is true that GH does affect the secretion of glucagon in the liver (it inhibits it when present so as to increase protein growth, which is its function).</p><p></p><p>I have seen another paper that uses lab rats to prove this, and that paper starts with the claim that glucose uptake does not use insulin. I am not convinced that either paper offers sufficient proof to be held up as a valid contender to the established theme of the Krebs and Randle cycles as taught in the endocrinology textbooks.</p><p></p><p>Note Glucagon not only assists glucose uptake but it is also used for ketosis and ketone generation. and catabolization. In other words, glucagon being detected just means the blood glucose level is low or very low. It is in effect the fat-adapted switch.</p><p></p><p>If this claim regarding not requiring insulin was significant then T1D would survive longer without injecting insulin. The articles I have seen in this respect show that DKA normally requires meals to trigger it and that low carb can be effective in delaying DKA onset.</p><p><a href="https://www.healthline.com/diabetesmine/ask-dmine-lifespan-sans-insulin" target="_blank">https://www.healthline.com/diabetesmine/ask-dmine-lifespan-sans-insulin</a></p><p></p><p>It seems this claim comes from a single source P H Sonkson, who appears to be a sports health physician. Edit to add: He is indeed an endocrinologist, He was a Professor, and specialized in diabetes, moving on to Growth Hormone research. After his skiing accident, he had to change course and is now working in the field of detecting drug abuse in sports up to the Olympics level. I must read his papers again in that light.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2434156, member: 196898"] I have one problem with the linked article in the OP. Its Reference[21] which he uses as evidence to support the claim that insulin is not required for glucose uptake is actually a report looking into sport use of Growth Hormone, and finding ways to detect this drug abuse in athletes. Now it is true that GH does affect the secretion of glucagon in the liver (it inhibits it when present so as to increase protein growth, which is its function). I have seen another paper that uses lab rats to prove this, and that paper starts with the claim that glucose uptake does not use insulin. I am not convinced that either paper offers sufficient proof to be held up as a valid contender to the established theme of the Krebs and Randle cycles as taught in the endocrinology textbooks. Note Glucagon not only assists glucose uptake but it is also used for ketosis and ketone generation. and catabolization. In other words, glucagon being detected just means the blood glucose level is low or very low. It is in effect the fat-adapted switch. If this claim regarding not requiring insulin was significant then T1D would survive longer without injecting insulin. The articles I have seen in this respect show that DKA normally requires meals to trigger it and that low carb can be effective in delaying DKA onset. [URL]https://www.healthline.com/diabetesmine/ask-dmine-lifespan-sans-insulin[/URL] It seems this claim comes from a single source P H Sonkson, who appears to be a sports health physician. Edit to add: He is indeed an endocrinologist, He was a Professor, and specialized in diabetes, moving on to Growth Hormone research. After his skiing accident, he had to change course and is now working in the field of detecting drug abuse in sports up to the Olympics level. I must read his papers again in that light. [/QUOTE]
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