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Is T1 diabetes preventable?
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<blockquote data-quote="phoenix" data-source="post: 696663" data-attributes="member: 12578"><p>re those pesky Inuits. They don't seem to get <a href="http://journals.co-action.net/index.php/ijch/article/viewFile/17402/19720" target="_blank">LADA.(</a>they get T2) They quite probably don't have the genetic predisposition for it. A group of Inuits who were DNA tested were found to have a <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754547/pdf/IJCH-72-21350.pdf" target="_blank">unique pattern of HLA alleles </a>unlike those in the rest of Canada and the world (i<em>t is variations in these genes, concerned with the immune system that are associated with both T1 and LADA. People with ancestors from the UK and in Scandinavia have a higher probability of carrying these gene variations than most of the rest of the world</em> )</p><p>The Inuits do though have their own particular gene variations which presumably fit their particular environmental niche. <a href="http://www.ncbi.nlm.nih.gov/books/NBK1527/" target="_blank">One that is very common</a> , quite surprisingly <strong>reduces </strong>their ability to manufacture ketones They can make some but a reduced amount They would therefore be very much less likely to be able to develop DKA(<em>increased infant mortality though , children suffer from </em><a href="http://www.ohsu.edu/xd/education/schools/school-of-medicine/academic-programs/graduate-programs-human-nutrition/programs/combined-di-masters/upload/Sarah-Lowe-manuscript.pdf" target="_blank"><em>impaired fasting tolerance </em></a><em>and overnight hypoglycaemia can be fatal</em>. )</p><p>I doubt though that any of us have many Inuit ancestors.</p></blockquote><p></p>
[QUOTE="phoenix, post: 696663, member: 12578"] re those pesky Inuits. They don't seem to get [URL='http://journals.co-action.net/index.php/ijch/article/viewFile/17402/19720']LADA.([/URL]they get T2) They quite probably don't have the genetic predisposition for it. A group of Inuits who were DNA tested were found to have a [URL='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754547/pdf/IJCH-72-21350.pdf']unique pattern of HLA alleles [/URL]unlike those in the rest of Canada and the world (i[I]t is variations in these genes, concerned with the immune system that are associated with both T1 and LADA. People with ancestors from the UK and in Scandinavia have a higher probability of carrying these gene variations than most of the rest of the world[/I] ) The Inuits do though have their own particular gene variations which presumably fit their particular environmental niche. [URL='http://www.ncbi.nlm.nih.gov/books/NBK1527/']One that is very common[/URL] , quite surprisingly [B]reduces [/B]their ability to manufacture ketones They can make some but a reduced amount They would therefore be very much less likely to be able to develop DKA([I]increased infant mortality though , children suffer from [/I][URL='http://www.ohsu.edu/xd/education/schools/school-of-medicine/academic-programs/graduate-programs-human-nutrition/programs/combined-di-masters/upload/Sarah-Lowe-manuscript.pdf'][I]impaired fasting tolerance [/I][/URL][I]and overnight hypoglycaemia can be fatal[/I]. ) I doubt though that any of us have many Inuit ancestors. [/QUOTE]
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