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Is the CIM really dead or...
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<blockquote data-quote="Member496333" data-source="post: 2459118"><p>To be fair I wasn't replying or referring to yourself at all. Just a passing comment. There are lots of folk, particularly in the health and fitness sectors, who will argue to the death that insulin has nothing to do with obesity.</p><p></p><p>In the end, insulin, among many other factors I have no doubt, is the gatekeeper of energy storage and partitioning. It's the primary variable that determines whether glucose energy is used for fuel there and then, stored safely as fat, or in extreme cases, simply left to accumulate in its absence and become toxic. You also can't really burn body fat for fuel when circulating insulin is excessive, but you can most certainly make fat from glucose in the same setting.</p><p></p><p>In my mind, the energy in/out model is valid, but all the variables are heavily influenced by CIM, so I don't think it's necessarily one or the other. Rather it's a complex relationship between the two.</p></blockquote><p></p>
[QUOTE="Member496333, post: 2459118"] To be fair I wasn't replying or referring to yourself at all. Just a passing comment. There are lots of folk, particularly in the health and fitness sectors, who will argue to the death that insulin has nothing to do with obesity. In the end, insulin, among many other factors I have no doubt, is the gatekeeper of energy storage and partitioning. It's the primary variable that determines whether glucose energy is used for fuel there and then, stored safely as fat, or in extreme cases, simply left to accumulate in its absence and become toxic. You also can't really burn body fat for fuel when circulating insulin is excessive, but you can most certainly make fat from glucose in the same setting. In my mind, the energy in/out model is valid, but all the variables are heavily influenced by CIM, so I don't think it's necessarily one or the other. Rather it's a complex relationship between the two. [/QUOTE]
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