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is the role of insulin on the intestines being underestimated

M

mikwell

Active Member
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33
Type of diabetes
Treatment type
Diet only
Spontaneous intestinal perforations in extremely premature infants are associated with glucocorticoid-induced thinning of the ileal bowel wall. We have previously demonstrated that insulin-like growth factor-1 (IGF-1) is abundant within the submucosa of the newborn mouse ileum but is diminished by glucocorticoid exposure, concomitant with bowel wall thinning. These findings prompted us to hypothesize that IGF-I governs submucosal growth during neonatal gut development and that diminished IGF-I abundance results in submucosal thinning. Heterozygous IGF-I knockout, wild type and homozygous IGF-I over-expresser newborn mice were euthanized at 3 d of life. Additionally, wild type newborn mice received daily dexamethasone (DEX) (1μg/gm/d) or vehicle control on days of life 1 and 2 and were also euthanized at 3 d of life. Their ileums were harvested, fixed and the resulting sections were processed in parallel for IGF-I immunohistochemistry and morphometric measurements of submucosal thickness and bowel diameter. Immunolocalization of IGF-I in each genotype was also compared with that seen in DEX-treated and control mice euthanized at the same time of life. IGF-I heterozygous knockouts had diminished submucosal IGF-I immunolocalization (similar to that seen in DEX-treated newborn mice) whereas homozygous IGF-I over-expressers exceeded that seen within wild type mice. IGF-I genotype and submucosal abundance was positively correlated with ileal submucosal thickness. DEX treatment of newborn mice diminished IGF-I and caused significant thinning of the submucosa compared with controls. Submucosal growth and thickness in the neonatal mouse ileum is governed by IGF-I and is diminished by dexamethasone treatment.

Ok if insulin is supposed to be absorbed straight into the bloodstream how is there an abundance of insulin found in the submucosa layer of the intestine

http://www.nature.com/pr/journal/v55/n3/abs/pr200479a.html
 
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1)No, it's not the same . In fact people who have genetic conditions resulting in low IGF-1 apparently are less likely to develop diabetes. (but have other problems )
2) If the gut made insulin then this research which is essentially genetically modifying 'gut' cells to change them to insulin producing cells would be totally redundant .

You just seem to be picking out words out of context.
 
are you going to start a new thread on this every week?
why didn't you post this on your existing thread where you have posted this stuff?
 
mikwell said:
Nope without insulin there would be no IGF 1 . low insulin = low IGF 1 .They are basically the same hormone do the exact same .plus insulin still aids recovery and helps with food absorption from the gut and is secreted all over the intestineshttp://m.medicalxpress.com/news/2012-02-diabetes-intestines.html
Click to expand...

IGF-1 is a banned substance in professional sport....
Check out the list of sporting type 1's here.. http://en.m.wikipedia.org/wiki/List_of_sportspeople_with_diabetes
Then make a connection with what you believe they ere injecting for diabetes management with the position they hold....! ;)
 
Jaylee said:
IGF-1 is a banned substance in professional sport....
Check out the list of sporting type 1's here.. http://en.m.wikipedia.org/wiki/List_of_sportspeople_with_diabetes
Then make a connection with what you believe they ere injecting for diabetes management with the position they hold....! ;)
Click to expand...
Hey look if i was to experiment with insulin to see would it help with some of my discomfort and stress which insulin should i go for for an experiment, i have alot of symptoms and i was warned my blood flow is bad i have cramps in my legs now which is new
what do you think would be the best price wise and propper insulin
 
mikwell said:
Hey look if i was to experiment with insulin to see would it help with some of my discomfort and stress which insulin should i go for for an experiment, i have alot of symptoms and i was warned my blood flow is bad i have cramps in my legs now which is new
what do you think would be the best price wise and propper insulin
Click to expand...
You can't buy insulin - it's prescription only medicine. Otherwise is sounds like you would be up for a Darwin award.
 
oh believe me i know it seems mad that i go against the majority; but its a messed up world, there is to many deaths from diabetes, and people tend just to do what superiors tell them that can not be right
 
mikwell said:
Hey look if i was to experiment with insulin to see would it help with some of my discomfort and stress which insulin should i go for for an experiment, i have alot of symptoms and i was warned my blood flow is bad i have cramps in my legs now which is new
what do you think would be the best price wise and propper insulin
Click to expand...

Thankfully , as @robert72 has said, you will not be able to access insulin . If you could and did experiment on yourself, you would be dicing with death. And not from diabetes either.

Signy
 
robert72 said:
You can't buy insulin - it's prescription only medicine. Otherwise is sounds like you would be up for a Darwin award.
Click to expand...
sometimes I think we should let natural selection take its course. Could someone hand that man a pair of scissors, so he can go jogging
 
mikwell said:
oh believe me i know it seems mad that i go against the majority; but its a messed up world, there is to many deaths from diabetes, and people tend just to do what superiors tell them that can not be right
Click to expand...

Dude, your looking to "self prescribe". Based on what you have posted here as your "knowledge" & understanding of type1 diabetes, I would advise against this fool hardiness!!

See your doctor...
I'm a "stick it to the man" kinda guy... But I also work with proven science, then find my own path from there..
You have a bee in yer bonnet about a health issue that worries you. I understand that. But without a full professional check up, your barking up the wrong tree...

I wish you all the best!
 
hey look the body needs IGF1 just like it needs insulin in diabetes the pancreas is disfunctional but type 2 is different the pancreas is functional but not adapted to working with a arisen problem. If the main function of insulin is to deal with blood sugars what about all the other functions- which insulin definitely has - . Low insulin = low IGF1 = rapid weight loss thrombosis, blindness, heart attack all with blood sugars being fine. Except in obesity where blood sugars are high from typical obese cholesterol
 
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Hey not to the point but what's the reason of the appendix ??
Jaylee said:
Dude, your looking to "self prescribe". Based on what you have posted here as your "knowledge" & understanding of type1 diabetes, I would advise against this fool hardiness!!

See your doctor...
I'm a "stick it to the man" kinda guy... But I also work with proven science, then find my own path from there..
You have a bee in yer bonnet about a health issue that worries you. I understand that. But without a full professional check up, your barking up the wrong tree...

I wish you all the best!
Click to expand...
 
mikwell said:
Hey not to the point but what's the reason of the appendix ??
Click to expand...
I'm going to hazard a guess.. & say it makes "good bacteria" for the gut...? Though no great loss if removed....

Go to a doctor...
 
For water digestion too much water it releases bacteria to treat the gut . Drink dirty water and it puts out bacteria to counter act the bacteria in the dirty water
 
mikwell said:
For water digestion too much water it releases bacteria to treat the gut . Drink dirty water and it puts out bacteria to counter act the bacteria in the dirty water
Click to expand...
Lucky for me I still have mine, so in the event of an apocalypse great news...!

See a bloody doctor....
 
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