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Type 1.5/LADA Diabetes
LADA/1.5 so confused??
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<blockquote data-quote="phoenix" data-source="post: 358880" data-attributes="member: 12578"><p>Elaine,</p><p>Just to pick up a couple of points. People with LADA have most typically GAD antibodies but there are several others including ICA, islet cell auto antibodies and IA-2 auto antibodies Those with GAD and IA-2 auto antibodies progress more rapidly to insulin dependency than those with GAD auto antibodies alone.</p><p>I have also read and it makes sense that those with higher numbers of antibodies tend to progress more quickly. About 80% of people who are GADA positive will progress to requiring insulin within 6 years.</p><p>I don't know of any evidence on the heritability of LADA. I know everyone worries , I was a grandmother before I developed it so worry sometimes about children and grandchildren. if the mother has T1 it's between a 1 in 25 and a 1in 100 but if someone has one autoimmune disease then they are susceptible to developing another ( Though some types of hypothyroidism are autoimmune I'm not sure that congential hypothyroidism is one of them, you'll know more about that than I)</p><p><a href="http://www.diabetes.org/diabetes-basics/genetics-of-diabetes.html" target="_blank">http://www.diabetes.org/diabetes-basics ... betes.html</a></p><p></p><p>There isn't any clear evidence on the best treatment for LADA pre insulin. Some countries like the UK tend to use oral meds other countries put people straight onto low doses of insulin. A Cochrane report looked at the evidence available a couple of years ago came to no real conclusion except to suggest that the drug 'sulphonylurea (like glibenclamide or glyburide, gliclazide) could make patients insulin dependent sooner and it does not control blood sugar as well as insulin'</p><p><a href="http://summaries.cochrane.org/CD006165/interventions-for-latent-autoimmune-diabetes-lada-in-adults" target="_blank">http://summaries.cochrane.org/CD006165/ ... -in-adults</a></p><p></p><p>Personally I left going to the doctor very late (long story basically I'd moved to a different country and tried to avoid going to the docs, I self diagnosed T2) Eventually my beta cells gave up . I was quite ill with all the classic symptoms including rapid weight loss, frequent urination, thirst. When I gave in and went to the doctors, I was hospitalised with high ketones. I went onto insulin straight away... but really about 3 years from I noticed the first symptoms. During that period I was quite careful with diet using a low GI diet and I did a fair amount of exercise which I'm sure helped.</p><p> ( I think from that the loss of insulin function was very jerky and intermittent rather than a gradual slide downwards )</p><p></p><p> Almost 8 years later and I have on the whole felt very well, certainly an awful lot better than the immediate period before I was 'diagnosed' and went onto insulin. Undoubtedly insulin/counting carbs/weighing food can be a hassle but it hasn't stopped me doing anything I've wanted to do. (including doing 'mad' things like long distance running, walking and joining my grandchildren swimming in rough seas or ascending a climbing wall. )</p></blockquote><p></p>
[QUOTE="phoenix, post: 358880, member: 12578"] Elaine, Just to pick up a couple of points. People with LADA have most typically GAD antibodies but there are several others including ICA, islet cell auto antibodies and IA-2 auto antibodies Those with GAD and IA-2 auto antibodies progress more rapidly to insulin dependency than those with GAD auto antibodies alone. I have also read and it makes sense that those with higher numbers of antibodies tend to progress more quickly. About 80% of people who are GADA positive will progress to requiring insulin within 6 years. I don't know of any evidence on the heritability of LADA. I know everyone worries , I was a grandmother before I developed it so worry sometimes about children and grandchildren. if the mother has T1 it's between a 1 in 25 and a 1in 100 but if someone has one autoimmune disease then they are susceptible to developing another ( Though some types of hypothyroidism are autoimmune I'm not sure that congential hypothyroidism is one of them, you'll know more about that than I) [url=http://www.diabetes.org/diabetes-basics/genetics-of-diabetes.html]http://www.diabetes.org/diabetes-basics ... betes.html[/url] There isn't any clear evidence on the best treatment for LADA pre insulin. Some countries like the UK tend to use oral meds other countries put people straight onto low doses of insulin. A Cochrane report looked at the evidence available a couple of years ago came to no real conclusion except to suggest that the drug 'sulphonylurea (like glibenclamide or glyburide, gliclazide) could make patients insulin dependent sooner and it does not control blood sugar as well as insulin' [url=http://summaries.cochrane.org/CD006165/interventions-for-latent-autoimmune-diabetes-lada-in-adults]http://summaries.cochrane.org/CD006165/ ... -in-adults[/url] Personally I left going to the doctor very late (long story basically I'd moved to a different country and tried to avoid going to the docs, I self diagnosed T2) Eventually my beta cells gave up . I was quite ill with all the classic symptoms including rapid weight loss, frequent urination, thirst. When I gave in and went to the doctors, I was hospitalised with high ketones. I went onto insulin straight away... but really about 3 years from I noticed the first symptoms. During that period I was quite careful with diet using a low GI diet and I did a fair amount of exercise which I'm sure helped. ( I think from that the loss of insulin function was very jerky and intermittent rather than a gradual slide downwards ) Almost 8 years later and I have on the whole felt very well, certainly an awful lot better than the immediate period before I was 'diagnosed' and went onto insulin. Undoubtedly insulin/counting carbs/weighing food can be a hassle but it hasn't stopped me doing anything I've wanted to do. (including doing 'mad' things like long distance running, walking and joining my grandchildren swimming in rough seas or ascending a climbing wall. ) [/QUOTE]
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