I am on Lantus and Metformin and have been taking Byetta for a month. The consultant gave it to me although it is not licensed for use with Insulin. My Gp is happy to continue because my sugars yhave come down significantly, I have lost a little weight, am no longer ravenous all the time, and the pain in my feet is much reduced. I have had a little nausea but not bad enough to be a uisance and have just gone onto the full 10unit dose after being on 5units for the first 30 days,. I was taking Apidra as well as Lantus before 3 times a day and this has stopped. The sugar levels are now mostly in the normal range instead of in the high teens . Go for it if you can get it I say.