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LCHF diet and taking Simvastatin
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<blockquote data-quote="sanguine" data-source="post: 569954" data-attributes="member: 101256"><p>Sam, I applaud you for putting your point of view into what is an interesting discussion, you must feel you are in a small minority flying the flag for the pharm companies against an army of total cynics! Anyway,</p><p></p><p></p><p></p><p>OK good</p><p></p><p></p><p></p><p>Ah, but you understand our point that it's not the safety and regulatory aspects of the trials<em> per se</em> that's the issue (well it is a bit), but the availability of the data in those trials to entities that can carry out a truly independent review and audit of them. You say commercial confidentiality is an issue here, but again I would assume that all major pharm companies are doing very similar things and can certainly analyse each others' products, so what exactly is at stake, especially in the case of assessment of side effects?</p><p></p><p>Of course, if all the companies pooled their trial data and saved all that money for the common good - no, stupid idea, why would that work ...</p><p></p><p></p><p></p><p>But as Indy has pointed out (elsewhere if not here, maybe in the statins side-effects poll thread <a href="http://www.diabetes.co.uk/forum/threads/poll-side-effects-from-statins.58409/" target="_blank">http://www.diabetes.co.uk/forum/threads/poll-side-effects-from-statins.58409/</a> CoQ10 is a natural product - are you saying the natural CoQ10 that the statins inhibit also has these effects? I think I'd sooner have the 'real' one left intact thanks (the pharm companies are desperately trying to find something that focusses on cholesterol further down the biochemical evolution tree to avoid CoQ10 and dolichol inhibition, so what does that tell us?).</p><p></p><p></p><p></p><p>Well it does, once you get past the screaming 'don't take with grapefruit' bit. But how disingenuous is it not to mention CoQ10 in that respect if that is 'the symptom'? You can get muscle aches for all sorts of reasons, I haven't seen anyone on the statin poll thread say they've been to the GP complaining about muscle pain, and the GP says 'Oh that must be due to CoQ10 inhibition'. It usually seems to be more like 'well what do you expect at your age?. If the patient even realises the connection AND bothers to report it at all, AND if the GP then relays that back to NICE.</p></blockquote><p></p>
[QUOTE="sanguine, post: 569954, member: 101256"] Sam, I applaud you for putting your point of view into what is an interesting discussion, you must feel you are in a small minority flying the flag for the pharm companies against an army of total cynics! Anyway, OK good Ah, but you understand our point that it's not the safety and regulatory aspects of the trials[I] per se[/I] that's the issue (well it is a bit), but the availability of the data in those trials to entities that can carry out a truly independent review and audit of them. You say commercial confidentiality is an issue here, but again I would assume that all major pharm companies are doing very similar things and can certainly analyse each others' products, so what exactly is at stake, especially in the case of assessment of side effects? Of course, if all the companies pooled their trial data and saved all that money for the common good - no, stupid idea, why would that work ... But as Indy has pointed out (elsewhere if not here, maybe in the statins side-effects poll thread [url]http://www.diabetes.co.uk/forum/threads/poll-side-effects-from-statins.58409/[/url] CoQ10 is a natural product - are you saying the natural CoQ10 that the statins inhibit also has these effects? I think I'd sooner have the 'real' one left intact thanks (the pharm companies are desperately trying to find something that focusses on cholesterol further down the biochemical evolution tree to avoid CoQ10 and dolichol inhibition, so what does that tell us?). Well it does, once you get past the screaming 'don't take with grapefruit' bit. But how disingenuous is it not to mention CoQ10 in that respect if that is 'the symptom'? You can get muscle aches for all sorts of reasons, I haven't seen anyone on the statin poll thread say they've been to the GP complaining about muscle pain, and the GP says 'Oh that must be due to CoQ10 inhibition'. It usually seems to be more like 'well what do you expect at your age?. If the patient even realises the connection AND bothers to report it at all, AND if the GP then relays that back to NICE. [/QUOTE]
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