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LDL cannot cross the endothelium
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<blockquote data-quote="agwagw" data-source="post: 2170319" data-attributes="member: 415845"><p>I agree with the views that the traditional cholesterol hypothesis is seriously flawed. However, if the endothelium is damaged and for whatever reason inflammatory responses are triggered then all sorts of untoward consequences might follow. Macrophages spend their life roaming surfaces in the body, ingesting (endocytosing) all sorts of stuff and if they accumulate as parts of plaques, then the large biochemicals they are carrying - such as lipids - may play a role in the physical thickening.</p><p></p><p>A healthy endothelium will block many if not all unwanted intrusions but it does seem that many of us do not have healthy endothelia. My own approach (as a humble lipid biochemist) is to maximise omega 3 (fish oil, cold-pressed rapeseed, olive oil, omega 3 high butter such as Anchor, beef dripping from grass-fed cattle etc), minimise omega 6 (sunflower oils, generic 'vegetable' oils, margarine etc) and clearly no processed food using trans-fats that have been synthesised so as to be solid at room temperature. However, this is just a personal view, scientific evidence is taking a long time to become clear - there are so many vested interests and misconceptions (as Dr Kendrick points out) that waters will be muddy for a time yet. As ever, my views are just for interest and debate, I am not directing or prescribing anything <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="agwagw, post: 2170319, member: 415845"] I agree with the views that the traditional cholesterol hypothesis is seriously flawed. However, if the endothelium is damaged and for whatever reason inflammatory responses are triggered then all sorts of untoward consequences might follow. Macrophages spend their life roaming surfaces in the body, ingesting (endocytosing) all sorts of stuff and if they accumulate as parts of plaques, then the large biochemicals they are carrying - such as lipids - may play a role in the physical thickening. A healthy endothelium will block many if not all unwanted intrusions but it does seem that many of us do not have healthy endothelia. My own approach (as a humble lipid biochemist) is to maximise omega 3 (fish oil, cold-pressed rapeseed, olive oil, omega 3 high butter such as Anchor, beef dripping from grass-fed cattle etc), minimise omega 6 (sunflower oils, generic 'vegetable' oils, margarine etc) and clearly no processed food using trans-fats that have been synthesised so as to be solid at room temperature. However, this is just a personal view, scientific evidence is taking a long time to become clear - there are so many vested interests and misconceptions (as Dr Kendrick points out) that waters will be muddy for a time yet. As ever, my views are just for interest and debate, I am not directing or prescribing anything :) [/QUOTE]
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