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Lipotoxicity & beta cell death, should I be worried?

Sirzy

Sirzy

Well-Known Member
Messages
266
Location
Glasgow
Type of diabetes
Other
Treatment type
Insulin
I've been reading several threads and a couple of papers recently that suggest that dietry fat may not neccesarily be linked with an increase in 'bad' cholesterol. And, from some of the evidence posted by other memebers (i.e. they increased their dietry fat but their LDL didn't increase), there certainly seem to be some anecdotal evidence to support this.

I've been controlling my bg, since diagnosis, with a low carb diet and I'm very happy with my numbers, but I've been supplementing my diet with an increase in fat, not all 'bad' fats such as those found in diary etc, but nuts and olive oil too.

I'm not particularly worried about my choloesterol increasing, but what does trouble me is the affect dietry fat can have on beta cell death. As a type 2(?), preserving as many of my beta cells as I can for as long as I can, seems to be of the utmost importance. So surely this increase in my fat intake isn't good for me on this level?

Anybody know anything about this? A google search for references doesn't seem to bring much useful stuff up. :?

Cheers :)
 
It depends on the detail that you want.
I can give you a list of some relevant scientists : Frayn, Mc Garry, Boden, Schrauwen .
(do a pubmed search of their articles )
If you haven't a background in the field you might have to buy Frayns textbook on Metabolic regulation to even attempt to understand some of the papers. (I know I did)
 
Hi,

Have you tried Google scholar?

Search: Lipotoxicity

Search: Lipotoxicity beta cell death

I'm not going to pretend that I've read up on any of the results, but I imagine that the majority of research centres on a high-fat/high-carb intake (standard chips and doughnuts diet), but there might be something specific to a high-fat/low-carb intake.

I'm also not going to pretend that I know what 'Endoplasmic reticulum stress' is, but it sounds like a right pain in the ar.....
 
Thanks for your replies :)

I have done a google scholar search, and I've noticed that most of the papers refer to an 'an excess of fatty acids' causing problems with beta cells, but what constitutes an excess? Exceeding the daily recommeded intake of saturated fat or total fat?

I've found this paper which suggests an excess of fatty acids along with accumalated triglcerides is a problem, and as I follow a low-carb diet this wouldn't be an issue for me. However, I still feel abit nervous about the amount of fat I eat at the moment, it's not a huge amount, but it's still significantly more than I used to eat (I used to avoid cheese, cream and olive oil until I found out I had db).

Phoenix, I'll check out the references you posted and see if this makes things any clearer. I do have a scientific background, but still find myself a bit stymied by all the endocrinology jargon that is bandied about in these journal papers! :crazy:
 
slimtony said:
I'm also not going to pretend that I know what 'Endoplasmic reticulum stress' is, but it sounds like a right pain in the ar.....
Click to expand...

:lol:
 
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