Lisinopril and Bisoprolol?

I was on Perindopril and Bisoprolol, I’ve since been taken off the Bisoprolol. Neither had any effect on my BG levels.

cutting carbs worked wonderfully for me.

The treatment your hubby is on is not just because of the heart bypass operation but is aimed at improving a weak valve in the heart itself. The lisinopril is simply a commonly used Blood Pressure med, and is added to reduce stress and back pressure on the valve. Neither of these meds is linked to blood sugar levels as far as I am aware.
https://www.medicalnewstoday.com/articles/bisoprolol-oral-tablet

I have no problem with my levels while on similar combination therapy and I use Low Carb which controls my blood sugars well, and also reduces BP. In fact, I have actually reduced my diabetic medication recently, and am still getting reasonable levels.

I suspect that the stay in hospital for the op has encouraged carb creep following the Hospital food regime

Ah, I guess I should mention that I was on very low dosages. 4mg and 2mg respectively.

fumanchu said:

Oldvatr I know what it's for and that his heart needs support, but since his dose was increased from 5mg to 20mg he is having this problem, so it seems to be linked. (His heart op was over a year ago). He's had bloods done yesterday and we wait to see what the doc says. But we don't want them just to shove him on Metropolol - more pills don't always sort a probem, you know?

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Here is another study specifically on this aspect of that med.
https://pubmed.ncbi.nlm.nih.gov/2439808/
No association was detected. The test was using 10mg doses.

One study that was observational did find that bisoprolol can mask the symptoms of hypoglycemia, and can affect the rate at which blood sugars recover after a hypo event.

I am on 5 mg dose, so cannot give experience of 20 mg, but I have not seen any significant change in my levels, As I said, I have managed to reduce my diabetic meds since the op and still get good levels without changing my diet to compensate.

Has there been a change of meter since the op?
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One thing that may be changing is the hematocrit value of his blood, and this can affect meter readings.

Often a simple change in diet can have a huge effect - changing say a chocolate nightcap from one that has standard ingredients to one that has low sugar or artificial sweeteners could actually register a higher trend in readings. Maltose or Malitol is one such sweetener that gives this hidden effect. Most bgl meters are sensitive to Malitol. Some react to Sorbitol too. So check to see if what he is eating has recently changed to Low or Zero sugar,

fumanchu said:

Hubby is type 2 diabetic, diet-controlled for over ten years. Recent heart bypass results in new meds, Lisinopril and Bisoprolol Fumarate. After a couple of months on this his BG is rising steadily and he's getting upset. He has always been very good re diet and hardly ever cheats. Can't get his BG under 9, when for years it was ion the 6/7s. Any advice on how to cope with this? We're wondering if going on the Newcastle diet or similar would work - but it might not because this is caused by meds.

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Is his HbA1c rising in tandem with the noted self test results? I get the impression that this rise is steady and fairly gradual/ This is not usually indicative of a medication change per se, which is a step-change event, but points to a more gradual process being involved, such as Insulin Resistance building up, or pancreas output dropping.

A quick reset of the system using Newcastle or another 8 week Blood Sugar vlcal diet may remove the effect of IR buildup, and be useful to consider. It is difficult to give assistance when we do not know what his diet plan is or what he normally eats.

Does he snack much? You do say he rarely cheats, so probably not. But I have known people having similar rises, even when following strict diets that normally should work, but on investigation were not including the regular consumption of beer as a 'food item'. One person developed a secret craving for Tic Tacs and was actually consuming 2 packs a day. Another was a long-distance driver, who had fruit pastilles while he drove, then wondered why he could not get his sugars down. Since the level of glucose in the blood is directly related to the consumption of carbohydrates, then such extracurricular activities must also be declared.

Whilst there are some medications that raise bgl levels (statins, steroids for example) you should only suspect them when you have eliminated the other possible causes for a rise. Timing is possibly just a coincidence. I would not advise stopping the heart med to see if levels come down again. Best to play around with diet and lifestyle first,