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<blockquote data-quote="Daibell" data-source="post: 756391" data-attributes="member: 21149"><p>Yes, Gliclazide can cause weight gain I assume by getting the pancreas to produce more insulin and hence use up some of excess glucose in the blood? My understanding is that Januvia suppresses a DPP-4 enzyme that in turn switches insulin production off after a meal hence the time is extended and yes it has no effect once your BS in normal. Both these drugs appear to be indicated if you are slim and effectively an early LADA like I was. I can't remember how the Glitazones work. I wonder whether your calorie restricted diet still had too many carbs? Fat is much higher calorie than carbs weight for weight and is why I have some reservations about the ND if your bs is way too high?</p></blockquote><p></p>
[QUOTE="Daibell, post: 756391, member: 21149"] Yes, Gliclazide can cause weight gain I assume by getting the pancreas to produce more insulin and hence use up some of excess glucose in the blood? My understanding is that Januvia suppresses a DPP-4 enzyme that in turn switches insulin production off after a meal hence the time is extended and yes it has no effect once your BS in normal. Both these drugs appear to be indicated if you are slim and effectively an early LADA like I was. I can't remember how the Glitazones work. I wonder whether your calorie restricted diet still had too many carbs? Fat is much higher calorie than carbs weight for weight and is why I have some reservations about the ND if your bs is way too high? [/QUOTE]
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