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Metabolic impairment from NAFLD worse in obese, type 2 diabetes patients than those without...

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In middle-aged obese patients with type 2 diabetes, the presence of non-alcoholic fatty liver disease (NAFLD) is associated with more adverse health effects compared to people without NAFLD, research suggests. NAFLD is a condition which involves a build-up of fat within the liver and increases the risk of cardiovascular problems, such as heart attack. It is particularly dangerous for people with type 2 diabetes who already have a heightened risk of cardiovascular disease. A research team at the University of Florida evaluated 154 patients with obesity and divided them into four groups: type 2 diabetes without NAFLD; type 2 diabetes with isolated steatosis (stage one of NAFLD); type 2 diabetes with non-alcoholic steatohepatitis (stage 2 of NAFLD); and a control group without type 2 diabetes or NAFLD. The researchers found that the isolated steatosis and NASH groups had higher hepatic (in the liver) triglyceride levels compared to the other two groups - high triglyceride levels can increase the risk of heart attack and stroke. No differences in triglyceride levels were found between controls and those with diabetes but without NAFLD. Those in the isolated steatosis or NASH groups had no significant association with poor blood pressure control, increased use of hypertensive medication or total or LDL cholesterol; but the NASH group had lower HDL and higher plasma triglycerides compared to type 2 or control patients. Patients with type 2 diabetes (with or without NAFLD) had similar elevations in fasting plasma glucose levels and HbA1c compared to controls. Also, the isolated steatosis and NASH participants had increased fasting plasma insulin, which is known as hyperinsulinemia. "In middle-aged obese patients with [type 2 diabetes], the presence of NAFLD is associated with hyperinsulinemia and more severe adipose tissue and hepatic insulin resistance, as well as worse atherogenic dyslipidemia," the authors wrote. "The clinical implication is that the presence of NAFLD in patients with [type 2 diabetes] should alert the health care provider to institute a more aggressive lifestyle intervention and consider strategies to minimize high cardiovascular risk." People with NAFLD are recommended to monitor their weight through eating a health diet and getting regular exercise. Furthermore, quitting smoking and avoiding alcohol can prevent NAFLD from becoming worse. The findings appear in the online journal Diabetes Care.

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Also anyone with NAFLD who has tried to lose weight will know this too.

It's a pity they don't also say that limiting carb intake and not having diet drinks will help this condition too.
 
NoCrbs4Me said:
If someone with NAFLD assumed that eating a healthy diet meant following the NHS healthy plate guidelines and did just that, their NAFLD would not improve.
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Weightloss is by far the most imporant aspect. Look at Roy Taylor research and his ct scans of liverfat content in people having undergone the newcastle diet. The liver fat content is very different after the 8 weeks. So yeah, you can achieve the weightloss with a lowcarb diet, but also with others mean so, weightloss is the most important.
 
Roytaylorjasonfunglover said:
Weightloss is by far the most imporant aspect. Look at Roy Taylor research and his ct scans of liverfat content in people having undergone the newcastle diet. The liver fat content is very different after the 8 weeks. So yeah, you can achieve the weightloss with a lowcarb diet, but also with others mean so, weightloss is the most important.
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A very low calorie diet is also a low carb diet.
 
NoCrbs4Me said:
A very low calorie diet is also a low carb diet.
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As long as you reset your bodyweight setpoint to a lower level with unprocessed foods, you can do this in a variety of ways, a lowcarb diet, a highcarb diet, may both achieve this as long as they conists of mostly unprocessed foods. Eating some kg of plain boiled potatoes is not the same as eating chips and washing it down with a coke, and eating a plain ox steak, is not the same as eating process lunchmeats.

Weight loss is the alpha and omega like jesus used to say.
 
Roytaylorjasonfunglover said:
Weight loss is the alpha and omega like jesus used to say.
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I agree it seems to be for most people, but I for one find it difficult to lose weight. I have found that if I low carb my fatty liver improves dramatically even when not accompanied by substantial weight loss. When I eat too many carbs it gets worse again even if I don't gain any weight. This is just a personal observation and I may be the only one it applies to, but I am aiming to cure my fatty liver in order for my metabolism to work better so that I may then lose weight. Trust me to be difficult huh? ;)
 
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