Hi just to add my personal experience to this. I had been taking 2 x Metformin without too many issues before I started serious fasting last October / November when I did a month of one meal a day and no cream or broth just black coffee, tea and water in the 23 hours without food. Boy did I have problems with my guts, I couldn’t get hold of a dn on phone and awAy from home at time so,as my bloods were low anywAy by that stage as I had done LCHF for a month beforehand, I made a decision to ditch the pills and felt so much better. Not advising this to anyone just telling you what I decided for me as I couldn’t live with the gut pain. All pain stopped when stopped meds and at my review in early December when had been off met for 6 weeks my hbaca1 was down to 33 so DN said I didn’t need them any more. Never taken them since will be interesting what this coming review is like in two weeks time after 6 months without Metformin. My guts clearly couldn’t handle Metformin without food. Interestingly too my bloods didn’t go up even though I went cold turkey off the mets.