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Metformin and Risk of Vitamin B12 Deficiency
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<blockquote data-quote="D._Activist" data-source="post: 1497680" data-attributes="member: 290343"><p>Hi Johnnyx!</p><p></p><p>Metformin does indeed cause B12 deficiency... which if it progresses can lead to B12 deficiency dementia. This is a particular problem in people who also have the MTHFR gene abnormality as they are unable to utilize regular B6 (something most people with D are deficient in) and thereby unlock and utilize B12 for energy etc. B12 can accumulate to high levels but be locked up and inaccessible. 5-MTHF or Methyltetrahydrofolate can assist this abnormality but there are other factors that medicine doesn't work with that can effect your nutrient status... the least of them being diarrhea or frequent urination both which deplete the body of water soluble vitamins like B's and minerals. Doctors in my country are not sanctioned to provide nutritional recommendations so those of us who have D and work with nutrition are best sources for this kind of problem solving. Nutrient status is critical to health and when B vitamins are dis-regulated a cascade of other problems occur.</p><p></p><p>Carbohydrates are officially listed as insulin antagonists "against insulin" so common sense would dictate that restriction is a good thing. Added to this many D people do not make amylase which is the primary enzyme for metabolism of carbohydrates.</p><p></p><p>So... is metformin bad? If you want optimal health yes.</p><p>Are carbs bad? Not if viewed with health in mind proper sources in mind and in small amounts.</p><p></p><p>All Diabetes drugs whether insulin or others, carry side effects, some that disrupt the very endocrine function they are designed to treat... so working to get educated and finding the individual plan that can decrease drugs to a minimum and build health is the best answer.</p></blockquote><p></p>
[QUOTE="D._Activist, post: 1497680, member: 290343"] Hi Johnnyx! Metformin does indeed cause B12 deficiency... which if it progresses can lead to B12 deficiency dementia. This is a particular problem in people who also have the MTHFR gene abnormality as they are unable to utilize regular B6 (something most people with D are deficient in) and thereby unlock and utilize B12 for energy etc. B12 can accumulate to high levels but be locked up and inaccessible. 5-MTHF or Methyltetrahydrofolate can assist this abnormality but there are other factors that medicine doesn't work with that can effect your nutrient status... the least of them being diarrhea or frequent urination both which deplete the body of water soluble vitamins like B's and minerals. Doctors in my country are not sanctioned to provide nutritional recommendations so those of us who have D and work with nutrition are best sources for this kind of problem solving. Nutrient status is critical to health and when B vitamins are dis-regulated a cascade of other problems occur. Carbohydrates are officially listed as insulin antagonists "against insulin" so common sense would dictate that restriction is a good thing. Added to this many D people do not make amylase which is the primary enzyme for metabolism of carbohydrates. So... is metformin bad? If you want optimal health yes. Are carbs bad? Not if viewed with health in mind proper sources in mind and in small amounts. All Diabetes drugs whether insulin or others, carry side effects, some that disrupt the very endocrine function they are designed to treat... so working to get educated and finding the individual plan that can decrease drugs to a minimum and build health is the best answer. [/QUOTE]
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