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Metformin - Benefits of low dose compared to stopping
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<blockquote data-quote="Brunneria" data-source="post: 1985751" data-attributes="member: 41816"><p>Hi,</p><p></p><p>The HbA1c is to measure blood glucose, not heart issues.</p><p>BUT people with high insulin (aka insulinaemia) often also develop type 2 diabetes and metabolic syndrome, and heart issues are an increased risk too.</p><p></p><p>The problem with linking HbA1c directly to heart risk is that people can have beautifully low HbA1cs yet have high insulin levels, with all the attendent knock on health effects except for high blood glucose. Sad but true.</p><p></p><p>I can give you specific references on this if you like (i will have to dig them out), but they will basically be about Kraft’s study on insulin resistance and links to heart disease, and Ivor Cummins lectures on hyperinsulinaemia ‘the elephant in the room’.</p><p></p><p>I completely agree with you that keeping insulin levels low by controlling blood glucose and minimising spikes, is a priority.</p><p></p><p>Well done on that CAC score! No small achievement.</p></blockquote><p></p>
[QUOTE="Brunneria, post: 1985751, member: 41816"] Hi, The HbA1c is to measure blood glucose, not heart issues. BUT people with high insulin (aka insulinaemia) often also develop type 2 diabetes and metabolic syndrome, and heart issues are an increased risk too. The problem with linking HbA1c directly to heart risk is that people can have beautifully low HbA1cs yet have high insulin levels, with all the attendent knock on health effects except for high blood glucose. Sad but true. I can give you specific references on this if you like (i will have to dig them out), but they will basically be about Kraft’s study on insulin resistance and links to heart disease, and Ivor Cummins lectures on hyperinsulinaemia ‘the elephant in the room’. I completely agree with you that keeping insulin levels low by controlling blood glucose and minimising spikes, is a priority. Well done on that CAC score! No small achievement. [/QUOTE]
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