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Metformin question (again)
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<blockquote data-quote="DavidGrahamJones" data-source="post: 1454105" data-attributes="member: 245335"><p>Sorry, I wasn't trying to make a connection. The arthritis is why I was taking cocodomol which negated the diarrhea effects of Metformin. As for the cause of Arthritis, that's a tricky one. The GP who first diagnosed arthritis called it osteo-rheumatoid arthritis and I thought he was just covering his bets. The consultant at Wycombe Hospital who I saw first asked almost straight away if I had played rugby, badmington/squash or jogged, so he got 3 out of 3, very perceptive but definitely leaning towards osteoarthritis. Having said that he did say that there is a rheumatoid element to osteoarthritis which weakens the cartilage before starting to wear more quickly than normal.</p><p></p><p>I believe that type II was being redefined as an autoimmune disease rather than purely metabolic as far back as 2011. Researchers believe that insulin resistance is the result of B cells and other immune cells attacking the body's own tissues. Maybe there's a connection between my old knees and diabetes. Knees now replaced at my expense because the NHS said I was too fat, thanks to Rosiglitazone and Citilapram, and too young, and warranted for 30 years.</p></blockquote><p></p>
[QUOTE="DavidGrahamJones, post: 1454105, member: 245335"] Sorry, I wasn't trying to make a connection. The arthritis is why I was taking cocodomol which negated the diarrhea effects of Metformin. As for the cause of Arthritis, that's a tricky one. The GP who first diagnosed arthritis called it osteo-rheumatoid arthritis and I thought he was just covering his bets. The consultant at Wycombe Hospital who I saw first asked almost straight away if I had played rugby, badmington/squash or jogged, so he got 3 out of 3, very perceptive but definitely leaning towards osteoarthritis. Having said that he did say that there is a rheumatoid element to osteoarthritis which weakens the cartilage before starting to wear more quickly than normal. I believe that type II was being redefined as an autoimmune disease rather than purely metabolic as far back as 2011. Researchers believe that insulin resistance is the result of B cells and other immune cells attacking the body's own tissues. Maybe there's a connection between my old knees and diabetes. Knees now replaced at my expense because the NHS said I was too fat, thanks to Rosiglitazone and Citilapram, and too young, and warranted for 30 years. [/QUOTE]
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