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Message: <blockquote data-quote="DCUKMod" data-source="post: 1658137" data-attributes="member: 345386">I'd say most people, if they're to have unwanted side-effects will experience them at a level their body doesn't like.  In your case, on adding the third tablet.For many the side-effects fade over a couple of weeks, but for others they persist, and usually the Doc will prescribe a modified release version of the tablet, which is often more tummy friendly.Some report changes to their mood when starting new drugs, but that could also be a reaction to your diagnosis.  That's usually a bit of a blow and takes a bit of getting used to.If you are having chest pains then a quick word with 111 might put your mind at rest, but otherwise, in your shoes I'd consider whether to stick with all 3 tablets a day or whether to drop back to 2 again for a few days to let things settle before trying again or talking to the Doc when you go next week.  I'm not a Doc so couldn't consider telling you what to do, I'm just explaining how my own thought process might work.Metformin works by building up to therapeutic levels in your system over several days, so a couple of lower doses isn't likely to have any massive impact to your blood sugar levels.Good luck with it all.</blockquote>

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