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Metformin ~ slow release or not?
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<blockquote data-quote="Swan2019" data-source="post: 2671651" data-attributes="member: 583943"><p>I asked my doctor to change me to the slow release formulation as felt it might give better control as was having too many ups and downs with the blood glucose readings. He did say that it was normally once a day, which I questioned as most scripts I dispensed for it were for twice daily. He did do it as twice daily. I looked it up in the book that gives all drug dosages and this it what it says…</p><p></p><p>Initially 500 mg once daily, then increased if necessary up to 2 g once daily, dose increased gradually, every 10–15 days, dose to be taken with evening meal, alternatively increased to 1 g twice daily, dose to be taken with meals, alternative dose only to be used if control not achieved with once daily dose regimen. If control still not achieved then change to standard release tablets.</p><p></p><p>As the effect of it peaks at around 6-7 hours it makes more sense to me for it to be twice daily.</p></blockquote><p></p>
[QUOTE="Swan2019, post: 2671651, member: 583943"] I asked my doctor to change me to the slow release formulation as felt it might give better control as was having too many ups and downs with the blood glucose readings. He did say that it was normally once a day, which I questioned as most scripts I dispensed for it were for twice daily. He did do it as twice daily. I looked it up in the book that gives all drug dosages and this it what it says… Initially 500 mg once daily, then increased if necessary up to 2 g once daily, dose increased gradually, every 10–15 days, dose to be taken with evening meal, alternatively increased to 1 g twice daily, dose to be taken with meals, alternative dose only to be used if control not achieved with once daily dose regimen. If control still not achieved then change to standard release tablets. As the effect of it peaks at around 6-7 hours it makes more sense to me for it to be twice daily. [/QUOTE]
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