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Metformin vs. Metformin Extended Release
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<blockquote data-quote="willmax" data-source="post: 1534068" data-attributes="member: 157106"><p>Hello,</p><p>I am type 1 diabetic of 68 years of duration. I have suffered from smelly flatulence and low bowel motility for at least 15 years. I was recently involved in a clinical trial to test whether Metformin improves carbohydrate metabolism and levels. The duration of the trial was 3 years. I lost about 4 kilos in weight and my HBa1c stabilised at 65-70mmol. I had never felt better. Last December (2016) the trial ended. My control worsened and HBa1c values increased too 90-100mmol. I tried to persuade my GP to give me Metformin but he consistently refused. There is a lack of correlation between clinical recommendations for NICE and in the USA and Canada where the latter two it has been reassessed and is recommended for therapy. But in the UK NICE guidelines state that use is not advised. I did a little research and after arranging for a colostomy where it was clear that I was constipated. I discovered that there are a group of enteric muscle/interneurons termed Golgi intrinsic cells. These are now considered to be the cells which drive/control/regulate gut motility or peristalsis. In long term type 1 diabetics the Golgi intrinsic cells are lost so that gut motility is reduced and or lost. The result is constipation and bloating. But my GP did not know anything of substance about the Golgi intrinsic cells - let alone how to treat patients who have reduced numbers of these cells in their gut wall. I admitted to hospital in February with cardiac failure from which I am partially recovering. But while in hospital I was proscribed Lactulose solution, about 15ml at each mealtime, and 2 Senna tablets at night. This has improved gut motility greatly and the stool is much softer and more passable two or three times a day. Also feel much less bloated and uncomfortable. Suggest try Lactulose solution which is available on proscription from your pharmacist in Scotland.</p><p></p><p>Best wishes,</p><p></p><p>William Maxwell</p></blockquote><p></p>
[QUOTE="willmax, post: 1534068, member: 157106"] Hello, I am type 1 diabetic of 68 years of duration. I have suffered from smelly flatulence and low bowel motility for at least 15 years. I was recently involved in a clinical trial to test whether Metformin improves carbohydrate metabolism and levels. The duration of the trial was 3 years. I lost about 4 kilos in weight and my HBa1c stabilised at 65-70mmol. I had never felt better. Last December (2016) the trial ended. My control worsened and HBa1c values increased too 90-100mmol. I tried to persuade my GP to give me Metformin but he consistently refused. There is a lack of correlation between clinical recommendations for NICE and in the USA and Canada where the latter two it has been reassessed and is recommended for therapy. But in the UK NICE guidelines state that use is not advised. I did a little research and after arranging for a colostomy where it was clear that I was constipated. I discovered that there are a group of enteric muscle/interneurons termed Golgi intrinsic cells. These are now considered to be the cells which drive/control/regulate gut motility or peristalsis. In long term type 1 diabetics the Golgi intrinsic cells are lost so that gut motility is reduced and or lost. The result is constipation and bloating. But my GP did not know anything of substance about the Golgi intrinsic cells - let alone how to treat patients who have reduced numbers of these cells in their gut wall. I admitted to hospital in February with cardiac failure from which I am partially recovering. But while in hospital I was proscribed Lactulose solution, about 15ml at each mealtime, and 2 Senna tablets at night. This has improved gut motility greatly and the stool is much softer and more passable two or three times a day. Also feel much less bloated and uncomfortable. Suggest try Lactulose solution which is available on proscription from your pharmacist in Scotland. Best wishes, William Maxwell [/QUOTE]
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