It seems the best way to start on Metformin is to increase the dose slowly then the stomach has more chance to adjust to it. My husband was told by his doctor to start on 1 tablet for 2 weeks then increase the dose every two weeks until he was on 2 tablets twice a day He did not have any problems but he was put on the SR ones straight awayive been on metformin for a week I take it twice a day plus insulin ,my tounge is very red and I always have an upset stomach does anyone else get this and does it wear off in time thanks