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Message: <blockquote data-quote="SimonCrox" data-source="post: 1590626" data-attributes="member: 388174">Metformin is as good as any other tablet at decreasing your glucose level.There is evidence that it decreases the risk of heart attack, stroke, death and some cancers, and it decreases othr complications of diabetes.It does not make folk gain weight or cause hypos.Basically, the more one takes, the more one gets in terms of glucose loewering and side effects; this works up to about 2.0 - 2.5 gm / day (Alan Garber paper a decade ago); above 2.5 gm per day, one does not greater glucose lowering, but one does get greater risk of side effects.Side effects are basically diarrhoea, poor appetite, feeling sick and wind. Best taken with foodSo, if you get side effects on 3 gm per day, you could usefully decrease the dose to 2gm per day; if this causes side effects, I would try the modified release variety.In a nutshell, 3gm per day is the top dose, and 2.5 gm per day would probably work just as well with less chance of side effects.best wishes</blockquote>

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