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Misdiagnosed as Type 1
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<blockquote data-quote="phoenix" data-source="post: 488310" data-attributes="member: 12578"><p>(Obviously your endo knows you and your medical history. I've certainly read of people over the age of 35 being diagnosed with MODY (sometimes parents have been diagnosed with T2 and it later transpires that they have MODY when their children are diagnosed). I suspect we read of more cases on forums because people with 'strange' conditions are perhaps more likely to seek more information because it's not readily available.</p><p> All MODY types are rare but they are becoming more recognised so may not be quite as rare as previously thought.</p><p>There are lots of different MODY types, I think these three are the most common.</p><p>HNFIA (MODY 3) is the most common type and you are most likely to develop it before 25 but can also develop at much later ages.</p><p></p><p> MODY 1 caused by a mutation in the HNF4A gene allows enough insulin to be produced in early childhood but this gradually reduces .The Exeter research group says</p><p></p><p>MODY 2( Glucokinase ) is a type that causes mildly elevated glucose throughout life and may often only be discovered on routine tests.(often during pregnancy)</p><p> </p><p>There is a MODY probability calculator of the Exeter website. It hasn't been properly validated but it might give an indication of any likelihood of having MODY.</p><p><a href="http://www.diabetesgenes.org/content/mody-probability-calculator" target="_blank">http://www.diabetesgenes.org/content/mody-probability-calculator</a></p><p> </p><p>But of course T2 also covers lots of different phenotypes (ie overweight, underweight, more insulin resistant, more insulin deficient) and has so far been associated with numerous genes (I think about 40 upwards so far) Unlike MODY it's probably a result of combinations of genes. The heritability of T2 ranges from 30-70% depending on study and the genes studied. It seems to be more heritable in some ethnic groups than others . It's hard fro researchers to calculate the heritability because families share not only genes but environment.</p><p> </p><p>Lots of info, some general, some very technical on the genetics of T1, T2 and MODY (but it is quite old and discoveries are being made all the time in this rapidly changing field.</p><p><a href="http://www.who.int/genomics/about/Diabetis-fin.pdf" target="_blank">http://www.who.int/genomics/about/Diabetis-fin.pdf</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 488310, member: 12578"] (Obviously your endo knows you and your medical history. I've certainly read of people over the age of 35 being diagnosed with MODY (sometimes parents have been diagnosed with T2 and it later transpires that they have MODY when their children are diagnosed). I suspect we read of more cases on forums because people with 'strange' conditions are perhaps more likely to seek more information because it's not readily available. All MODY types are rare but they are becoming more recognised so may not be quite as rare as previously thought. There are lots of different MODY types, I think these three are the most common. HNFIA (MODY 3) is the most common type and you are most likely to develop it before 25 but can also develop at much later ages. MODY 1 caused by a mutation in the HNF4A gene allows enough insulin to be produced in early childhood but this gradually reduces .The Exeter research group says MODY 2( Glucokinase ) is a type that causes mildly elevated glucose throughout life and may often only be discovered on routine tests.(often during pregnancy) There is a MODY probability calculator of the Exeter website. It hasn't been properly validated but it might give an indication of any likelihood of having MODY. [url]http://www.diabetesgenes.org/content/mody-probability-calculator[/url] But of course T2 also covers lots of different phenotypes (ie overweight, underweight, more insulin resistant, more insulin deficient) and has so far been associated with numerous genes (I think about 40 upwards so far) Unlike MODY it's probably a result of combinations of genes. The heritability of T2 ranges from 30-70% depending on study and the genes studied. It seems to be more heritable in some ethnic groups than others . It's hard fro researchers to calculate the heritability because families share not only genes but environment. Lots of info, some general, some very technical on the genetics of T1, T2 and MODY (but it is quite old and discoveries are being made all the time in this rapidly changing field. [url]http://www.who.int/genomics/about/Diabetis-fin.pdf[/url] [/QUOTE]
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