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Type 1 Diabetes
My insulin is not working.
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<blockquote data-quote="Celsus" data-source="post: 1768148" data-attributes="member: 185674"><p>Suggest you read The Lancet, Volume 5, No. 8, p567–569, August 2017...</p><p></p><p>"Fun thing" to observe is that Metformin is not to be taken by Diabetes Type1 patients taking insulin.</p><p>That is listed in its guidelines for market approval and counter indicator for its prescription/use across many countries.</p><p>Yes, I might now receive yet again a truckload of pushbacks from all out there who think its the greatest thing on earth... But reality is that the docs prescribing this to a Type1 is not following the medical guidelines and counter-indicators for this drug and its usage (in some countries!). And there are good reasons for why they are as they are. (Anyone wanting to go hypo overnight with no glucose left in your liver???)</p><p></p><p>I totally get why Metformin works well for type2s. Especially for those that then doesn't need to take insulin. </p><p></p><p>Personally I would never want to take more drugs at the same time than absolute necessary due to undesirable side-effects by combination of two or more pharma components. As a type 1 on insulin then Metformin is highly questionable even for low-insulin sensitive patients due to the simple facts of its channels of efficacy: Metformin decreases your hepatic glucose production, decreases the intestinal absorption of carbs you eat and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Just that it inhibits the hepatic glucose production is directly dangerous for a type1 in case we go hypo, as the natural gluconeogenesis process (the formation of glucose primarily from lactate and amino acids) is severely limited. Result being your body's ability to counter a hypo is challenged.</p><p></p><p>Next to this, depending on your metformin level in your system (which varies no matter how stable you take your drug) then depending on your intestines' ability to absorb the drug on any given day, your insulin will be more or less efficient to support the glucose metabolism. => ie. endless variation in how many units you need of fast acting insulin to counter eating 10 grams of carbs.</p><p></p><p>As type1 life wasn't hard enough already. </p><p>Anybody up for some Russian roulette?</p><p><going to make some tasty popcorns></p></blockquote><p></p>
[QUOTE="Celsus, post: 1768148, member: 185674"] Suggest you read The Lancet, Volume 5, No. 8, p567–569, August 2017... "Fun thing" to observe is that Metformin is not to be taken by Diabetes Type1 patients taking insulin. That is listed in its guidelines for market approval and counter indicator for its prescription/use across many countries. Yes, I might now receive yet again a truckload of pushbacks from all out there who think its the greatest thing on earth... But reality is that the docs prescribing this to a Type1 is not following the medical guidelines and counter-indicators for this drug and its usage (in some countries!). And there are good reasons for why they are as they are. (Anyone wanting to go hypo overnight with no glucose left in your liver???) I totally get why Metformin works well for type2s. Especially for those that then doesn't need to take insulin. Personally I would never want to take more drugs at the same time than absolute necessary due to undesirable side-effects by combination of two or more pharma components. As a type 1 on insulin then Metformin is highly questionable even for low-insulin sensitive patients due to the simple facts of its channels of efficacy: Metformin decreases your hepatic glucose production, decreases the intestinal absorption of carbs you eat and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Just that it inhibits the hepatic glucose production is directly dangerous for a type1 in case we go hypo, as the natural gluconeogenesis process (the formation of glucose primarily from lactate and amino acids) is severely limited. Result being your body's ability to counter a hypo is challenged. Next to this, depending on your metformin level in your system (which varies no matter how stable you take your drug) then depending on your intestines' ability to absorb the drug on any given day, your insulin will be more or less efficient to support the glucose metabolism. => ie. endless variation in how many units you need of fast acting insulin to counter eating 10 grams of carbs. As type1 life wasn't hard enough already. Anybody up for some Russian roulette? <going to make some tasty popcorns> [/QUOTE]
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