During my honeymoon period I think I was a bit in denial still, so, when it ended became very similar to how you described your wife, withdrawn, moody, not wanting to socialise etc. think it was because through my honeymoon phase thought theyve got this wrong,i can't be diabetic, then, end of honeymoon period and felt worse for a period of time than when I was originally diagnosed. Could be a fee things, body adjusting to becoming solely reliant on injcted insulin, the swings in levels while tweaking ratios who knows. Eventually did go to the docs and was on anti ds for 6 months which helped me through. Not saying your wife needs them,but, would advise to discuss with dsn,gp. Eventually, when things did settle sugar wise felt alot better, but, still have the odd "episode" usually when levels too high/low but very brief ones as they are soon in range again. Through it all I have had amazing support from family and friends and of course very suportive, and knowledgeable members here. Maybe suggests she joins as out certainly helps me to chat to others with the same issues as it can feel extremely lonely at times even with a supportive structure on place.