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"new" link between diet and atherosclerosis

C

Cowboyjim

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http://www.sciencedaily.com/releases/2012/10/121009131511.htm

Columbia University Medical Center (CUMC) researchers have found that a diet high in saturated fat raises levels of endothelial lipase (EL), an enzyme associated with the development of atherosclerosis, and, conversely, that a diet high in omega-3 polyunsaturated fat lowers levels of this enzyme.

The findings establish a "new" link between diet and atherosclerosis and suggest a novel way to prevent cardiovascular heart disease. In addition, the research may help to explain why the type 2 diabetes drug rosiglitazone (Avandia) has been linked to heart problems.

these results need to be confirmed in human studies," said Dr. Deckelbaum. "The findings might also explain some of the cardiovascular benefits that have been attributed to omega-3 fatty acids."

"So we hypothesized that if rosiglitazone activates ppar-gamma, it might also activate EL, which would explain its effects on the heart."

In a similar vein (groan)
http://www.sciencedaily.com/releases/2012/10/121009112129.htm
Using these mice to study how disruption of PPAR-gamma leads to high blood pressure, the researchers uncovered a new biological pathway (called the Cullin-3 pathway) in blood vessels, which may be the key to the blood pressure-lowering effects of TZD drugs.
thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are highly effective in controlling blood glucose levels and have an added benefit of lowering blood pressure in some patients. However, TZDs cause unrelated but potentially severe side effects in some patients
 
Hi all

This may be of interest to those following a low carb/high fat diet - although not yet confirmed in humans.

Regards

Doug
 
This study is based largely on conjecture and anecdotal evidence.
"Endothelial Lipase is an enzyme that shows to be increased in high-CV-risk patients, and reduced when omega-3 fatty acids are reduced in the diet."

This is similar to saying this:
Enzyme X is an enzyme that shows to be increased in high-CV-risk patients, and reduced when omega-3 fatty acids are reduced in the diet.

Without the bias that's in the article, you can look at this statement 1 of 2 ways:
1) Enzyme X directly causes CV disease in patients.
2) Enzyme X is present when CV disease is trying to be fixed naturally by the body.

This is the same paradigm that has demonized blood-cholesterol, when most current science is pointing to cholesterol as a repair mechanism in the heart which repairs micro-tears caused by insulin.

If you want to see these studies, I post the latest studies on my facebook page regularly for you to make up your own mind and critically think about the information being provided directly by these studies without media bias. (www.facebook.com/KetoLiving)
 
Many thanks for your post KetoLiving and for the service you provide in making the various studies about lipids and heart health available. We need to have knowledge and to be able to make informed decisions on our health care, as you say, without bias. Would it be possible for you to post the research items on this forum,perhaps in the news and research area?

Regards

Doug
 
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