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New method of treating type 1 diabetes proposed by US researcher
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<blockquote data-quote="LittleGreyCat" data-source="post: 2122855" data-attributes="member: 6467"><p>It is a bit "This is the problem. It is now your job to find the solution."</p><p></p><p>The first thing I would like to know is how insulin initially travels from the pancreas to the liver.</p><p>It is transferred via the blood stream, but does it go via a blood vessel directly to the liver before being released to the rest of the body?</p><p>I've searched for this but not found an answer so far.</p><p></p><p>Hmmm...hepatic portal vein was in the back of my mind and this does seem to carry blood directly from the internal organs including the pancreas to the liver. [As implied by the name.]</p><p>Easy if you guess the answer and work back to the question.</p><p></p><p>I can visualise that subcutaneous insulin injections are likely to send the insulin directly to all parts of the body, which in turn implies that much/most of the insulin may never get as far as the liver.</p><p></p><p>This in turn implies that you might in future be looking at some kind of "shunt" which inserts insulin into the blood stream into a vessel that carries a flow from the pancreas to the liver.</p><p></p><p>This would be much closer to an artificial pancreas.</p><p></p><p>This would also have major implications for insulin dosing. No more long acting basal, for example. Any insulin released would be in the liver in seconds.</p><p></p><p>Interesting stuff.</p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 2122855, member: 6467"] It is a bit "This is the problem. It is now your job to find the solution." The first thing I would like to know is how insulin initially travels from the pancreas to the liver. It is transferred via the blood stream, but does it go via a blood vessel directly to the liver before being released to the rest of the body? I've searched for this but not found an answer so far. Hmmm...hepatic portal vein was in the back of my mind and this does seem to carry blood directly from the internal organs including the pancreas to the liver. [As implied by the name.] Easy if you guess the answer and work back to the question. I can visualise that subcutaneous insulin injections are likely to send the insulin directly to all parts of the body, which in turn implies that much/most of the insulin may never get as far as the liver. This in turn implies that you might in future be looking at some kind of "shunt" which inserts insulin into the blood stream into a vessel that carries a flow from the pancreas to the liver. This would be much closer to an artificial pancreas. This would also have major implications for insulin dosing. No more long acting basal, for example. Any insulin released would be in the liver in seconds. Interesting stuff. [/QUOTE]
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