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Message: <blockquote data-quote="Melgar" data-source="post: 2728659" data-attributes="member: 520626">Hi there [USER=592706]@leylandCal94[/USER] , my understanding of LADA is that it is a slow destruction of beta cells due to an autoimmune trigger on the pancreas’ beta cells. The medical community seems to have drawn the line at 30 years old when diagnosing  for a possible LADA.  It is a slow progressing form of Type of T1. It is often called T1.5 because of the similarities with T2 in the early stages of progression. There seems to be a lot of confusion with many GPs who are not familiar with late onset T1, as they believe it to be T2. A form of confirmation bias because around 90% of people diagnosed with diabetes fall into the T2 category. Initially LADA follows the same trajectory of raised blood sugars as T2, however the two diseases are completely different. Differentiating LADA from T2 requires blood tests to see how much insulin the pancreas is producing and secreting ( Known as a C-Peptide test)  A low to normal insulin production does not rule out T1, but raised insulin production makes it far more likely T2. A definitive T1 diagnosis will depend on finding Autoantibodies. These tests are expensive and many Drs will not authorize them until your blood sugar HbAc1 tests are over 9% ( Canada) There are a number of autoantibodies types the body can produce.<ul> <li data-xf-list-type="ul">Glutamic Acid Decarboxylase Autoantibodies (GADA or Anti-GAD) This test looks for antibodies built against a specific enzyme in the insulin-producing pancreatic beta cells.</li> <li data-xf-list-type="ul">Insulin Autoantibodies (IAA) This tests looks for the antibodies targeting insulin.</li> <li data-xf-list-type="ul">Insulinoma-Associated-2 Autoantibodies (IA-2A) This test looks for antibodies mounted against a specific enzyme in beta cells. Both the IA-2A and GADA tests are common T1D antibody tests.</li> <li data-xf-list-type="ul">Zinc Transporter 8 (ZnT8Ab) This test looks at antibodies targeting an enzyme that is specific to beta cells.</li> <li data-xf-list-type="ul">Islet Cell Cytoplasmic Autoantibodies (ICA) Islet cells are clusters of cells in the pancreas that produce hormones, including insulin. This test identifies a type of islet cell antibodies present in up to 80 percent of people with T1D.</li> </ul>Some people can temporarily produce autoantibodies or produce antibodies but never  go on to develop T1 diabetes or they can produce autoantibodies temporarily due to an insult on the pancreas such as a virus.MODY or Maturity Onset Diabetes of the Young is a rare form of autosominal diabetes. It is caused by a mutation in the genes. As the name suggests it is diagnosed in younger adults. It is always suspected when 2 or more generations of family have diabetes.Ed for grammar</blockquote>

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