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Type 1 Diabetes
NHS for t1/2 and theories of t1
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<blockquote data-quote="AndyS" data-source="post: 562328" data-attributes="member: 20775"><p>Hi Beth,</p><p></p><p>In it's simplest terms it is because T1 is caused (usually) by an autoimmune response that kills off the beta cells that produce insulin. In terms of the number of people this will be, as best I understand the science, it is fairly constant as a percentage of the population. It is also something that cannot be fixed with diet or lifestyle changes. The fund raising is not to support people with it but to try and find: 1) What actually causes it and 2) a possible cure.</p><p>The thing is the mechanism for T1 is very very complex which is why your googling will not have turned up anything concrete.</p><p>The research that has been carried out has pointed to some areas where it is possible there could be the chances of a vaccine for people that are genetically predisposed. Though even this is still experimental.</p><p></p><p>T2 is something that is more or less a function of where society is headed with regards to waistlines (this is a MASSIVE over simplification so please hold off on flaming me for this statement) so that is what the government / NHS is budgeting additional funds for. The thing is that T2 can present slowly over time so people can live with it for years before diagnosis by which time a lot of damage could already have been done. T1 tends to be pretty much a binary thing where it is often (though not always) fairly clear cut that you have the condition.</p><p></p><p>As for evidence and theories.. well I have a history of autoimmune issues, for the majority of my life my immune system has been making a spirited attempt at killing me off (****** hasn't won yet, not for want of trying) but I can pinpoint the infections that triggered an immune response that then subsequently caused my last 2 issues. Ok so one of them was stress related but even so the chronology tracks in both cases. I will admit my experience would never stand up to proper scientific scrutiny and so therefore is more or less anecdotal but it all comes down to history and genetics.</p><p>In my case I know it is genetic (even though I am the only person in my family with issues, though I am an anomaly in many ways there anyway) as I got involved in some research studies and know that I carry certain genetic markers.</p><p></p><p>So it is kind of genetic though genes don't mean it is a definite, it is a genetic predisposition.</p><p></p><p>Unfortunately that is the best you will get for the moment as the science hasn't moved on enough just yet. It is a VERY grey area, there is no black and white answers right now.</p></blockquote><p></p>
[QUOTE="AndyS, post: 562328, member: 20775"] Hi Beth, In it's simplest terms it is because T1 is caused (usually) by an autoimmune response that kills off the beta cells that produce insulin. In terms of the number of people this will be, as best I understand the science, it is fairly constant as a percentage of the population. It is also something that cannot be fixed with diet or lifestyle changes. The fund raising is not to support people with it but to try and find: 1) What actually causes it and 2) a possible cure. The thing is the mechanism for T1 is very very complex which is why your googling will not have turned up anything concrete. The research that has been carried out has pointed to some areas where it is possible there could be the chances of a vaccine for people that are genetically predisposed. Though even this is still experimental. T2 is something that is more or less a function of where society is headed with regards to waistlines (this is a MASSIVE over simplification so please hold off on flaming me for this statement) so that is what the government / NHS is budgeting additional funds for. The thing is that T2 can present slowly over time so people can live with it for years before diagnosis by which time a lot of damage could already have been done. T1 tends to be pretty much a binary thing where it is often (though not always) fairly clear cut that you have the condition. As for evidence and theories.. well I have a history of autoimmune issues, for the majority of my life my immune system has been making a spirited attempt at killing me off (****** hasn't won yet, not for want of trying) but I can pinpoint the infections that triggered an immune response that then subsequently caused my last 2 issues. Ok so one of them was stress related but even so the chronology tracks in both cases. I will admit my experience would never stand up to proper scientific scrutiny and so therefore is more or less anecdotal but it all comes down to history and genetics. In my case I know it is genetic (even though I am the only person in my family with issues, though I am an anomaly in many ways there anyway) as I got involved in some research studies and know that I carry certain genetic markers. So it is kind of genetic though genes don't mean it is a definite, it is a genetic predisposition. Unfortunately that is the best you will get for the moment as the science hasn't moved on enough just yet. It is a VERY grey area, there is no black and white answers right now. [/QUOTE]
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