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Not sure what to make of OGTT results
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<blockquote data-quote="AdamJames" data-source="post: 1763051" data-attributes="member: 459333"><p>It was shown clearly in the first Newcastle study that it is possible to go from failing an OGTT to passing one, via the restoration of first-phase insulin response. The method used to achieve that was rapid weight loss. This corresponded to removal of fat from the liver (quite quickly) and the pancreas (more slowly).</p><p></p><p>There is good but not universally accepted evidence that what happened was that beta-cells which had stopped functioning due to fat content (inside the cells, interestingly, not surrounding them), once the fat was removed, started functioning again.</p><p></p><p>Another question mark is: if the method requires substantial weight loss, how sustainable is it? The stats for losing significant weight and keeping it off are not great, i.e. appalling.</p><p></p><p>Another question mark is time - it seems to get much less likely to succeed at around the 10 year mark from diagnosis.</p></blockquote><p></p>
[QUOTE="AdamJames, post: 1763051, member: 459333"] It was shown clearly in the first Newcastle study that it is possible to go from failing an OGTT to passing one, via the restoration of first-phase insulin response. The method used to achieve that was rapid weight loss. This corresponded to removal of fat from the liver (quite quickly) and the pancreas (more slowly). There is good but not universally accepted evidence that what happened was that beta-cells which had stopped functioning due to fat content (inside the cells, interestingly, not surrounding them), once the fat was removed, started functioning again. Another question mark is: if the method requires substantial weight loss, how sustainable is it? The stats for losing significant weight and keeping it off are not great, i.e. appalling. Another question mark is time - it seems to get much less likely to succeed at around the 10 year mark from diagnosis. [/QUOTE]
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Not sure what to make of OGTT results
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