• Guest - w'd love to know what you think about the forum! Take the 2025 Survey »

NovoRapid Profile

R

RichWatt

Member
Messages
18
Type of diabetes
Type 1
Hi,

I am trying to find a profile of how NovoRapid acts in the body once injected so that I can predict the rate at which my BG will come down after taking a shot. So far I have found very little help online in a common sense format. I've seen some charts and most sites say it reaches maximum affect in 3-5 hours but this is not what I am looking for.

I would like to know a % per hour or something similar, for example; end of 1st hour = 20% used up, end of 2nd hour 50% used up, end of 3rd hour 90% used up, end of 4th hour 100% used up. (these are just illustrative %'s I've made up).

Does anyone have this type of data from a trustworthy source?

I want to use this to make a simple model where I can input my BG and the insulin dose and see the profile of when my BG will normalise.

Thanks
 
The profile works out that it starts working within 15 minutes, then reaches it's peak at 2 hours, at this point 80% of the original dose has been used up the last 20% will lower the blood glucose by 1-2mmol/l over the last 2-3 hours... Dependant on how long it takes to burn out your system..

So if you took 10 units of novorapid, at the 2 hour mark it will have used 8 units, and leave 2 units which will burn off within the next 2-3 hours...

Hope this helps
 
I would agree with Jopar..

My post meal blood glucose predictor on my spreadsheet works on the follow:

0 - 30 mins: 5%
30 - 60 mins: 10%
60 - 90 mins: 15%
90 - 120 mins: 50%
120 - 240 mins: 20%

The action will be some what different for different people..
 
Hi,

If Novorapid's peak action is around the two-hour mark, might that explain why it covers my breakfast carbs just nicely but gives me a slight hypo about two hours after eating breakfast? I only have GDM, but the action would still be the same, wouldn't it? In which case I should probably move my morning snack up by about half an hour, to head it off at the pass!

The hospital didn't mention anything about this... Bah!

Jo
 
In the book "Think Like a Pancreas" by Gary Scheiner on page 168 he has a table that describes the typical action profile of rapid-acting insulin (Nova-Rapid).

It goes like this:

From time bolus taken:

30 min - 10% used 90% Insulin On Board (IOB)
60 min - 30% used 70% IOB
90 min - 50% used 50% IOB
120 min - 65% used 35% IOB
150 min - 80% used 20% IOB
180 min - 90% used 10% IOB
210 min - 95% used 5% IOB
240 min - 100% used

Great book by the way, would recommend it to all T1D who want to learn more about better control.

B.
 
This is something that I've recently been interested in. The technical term for the profile that you are talking about is a "pharmacokinetic curve", or as it's known in the business a "PK curve". It's part of my job to look at the PK curve for drugs (for cancer drugs though, not diabetes).

My recent HbA1c results have been a percent higher than I thought they should be based on what I wrote down in my home monitoring diary. My pre and post meal sugar levels were close to equal (post-meal being 2 hours after eating). But I recently discovered some hidden highs: I decided to do some tests an hour after eating and found that my sugar levels were going up by 7 or 8 mmol/l before coming back down to pre-meal levels by the time I did my post-meal test. I found that by injecting 20 mins before eating and switching to a low GI diet then my sugars don't rise at all. In technical terms my glucose PK curve (profile) and my insulin PK curve (profile) now match.

I urge everyone to check an hour after eating just to make sure that you are not getting any hidden highs. I'm yet to see whether this will bring my HbA1C down, but fingers crossed it will!
 
Back
Top