bedshaped2000
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reff:NSAIDs can cause or worsen the following conditions:
* Cardiovascular: Evidence from large research trials has showed increased rates of fatal and non-fatal cardiovascular events and heart attacks in patients taking NSAIDs.
* High blood pressure: NSAIDs can increase blood pressure. If you have high blood pressure, check with your doctor before using NSAIDs, especially if you take blood pressure lowering medication.
* Kidney disease: NSAIDs can cause kidney damage. If you already have any type of kidney disease, don't use NSAIDs. If while taking an NSAID, you develop sudden weight gain or fluid retention (for example, you notice swelling in your legs), notify your doctor right away.
* Diabetes: NSAIDs can cause a change in blood sugar. Check with your doctor before using NSAIDs if you have diabetes. You may still be able to use them, but you may need to follow your blood sugars closely and, with the help of your doctor, adjust your diabetes medications appropriately.
IBUPROFEN
NSAIDs possibly enhance effects of sulfonylureas (BG levels) Glicazide is
a sulfonylurea
Renal impairment
NSAIDs should be avoided if possible or used with caution in patients with renal impairment; the lowest effective dose should be used for the shortest possible duration, and renal function should be monitored. Sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure; deterioration in renal function has also been reported after topical use; see also individual drugs.
Hepatic impairment
NSAIDs should be used with caution in patients with hepatic impairment; there is an increased risk of gastro-intestinal bleeding and fluid retention. NSAIDs should be avoided in severe liver disease; see also individual drugs.
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