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Overweight vs underweight... which is harder to deal with?
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<blockquote data-quote="Daibell" data-source="post: 378839" data-attributes="member: 21149"><p><strong>Re: Overweight vs underweight... which is harder to deal wit</strong></p><p></p><p>Hi Kenny</p><p></p><p>Interesting question. I guess much of my diabetes knowledge has been acquired over the 8 years since my diagnosis. I've been monitoring this form for several years now taking on-board an enormous amount of information and download and viewed many articles. So, I suffer an overload of sources, many in conflict, but have a background understanding across the diabetes spectrum. I'll see what I can dig out, but one 1998 research paper (<a href="http://edrv.endojournals.org/content/19/4/491.long" target="_blank">http://edrv.endojournals.org/content/19/4/491.long</a> - note you can download the article in pdf as well) discusses the fact that most T2s start by having insulin deficiency and then develop, additionally, insulin resistance if overweight. This is an interesting view; have a read and see what you think. So, I think you are right in assuming being overweight doesn't cause T2, but the paper suggests that if you are genetically pre-disposed to diabetes then being overweight will bring about insulin resistance following insulin deficiency. This is new information to me. There are several known causes of pancreatic failure to produce insulin e.g. islet cell anti-bodies as in T1 or Late onset T1. There are several identified antibodies such as GAD, II4 if I remember correctly and a few others. Pancreatitis is know problem. Viruses are known to cause problems and I'm sure there are many other genetically triggered causes. Now, taking myself as a sample of one (!) I had a C-peptide test done privately in 2012 and it showed I had virtually no insulin production. This confirmed my suspicions that the tablets I was on were a relative waste of time and I needed insulin which I now have. Now some would say the Gliclazide I was taking killed my pancreas but as it never helped much anyway there probably weren't too many islet cells left to damage in the first place. My private GAD test was negative but it often is and there are other antibodies not tested for. So, I'm one of that 20% sub-group who probably don't have insulin resistance because I'm not overweight; my acquired opinion. Anyway I will dig around a bit more and see what I can find to back-up my 'opinion'. As I said in my OP, I was generalising but that's what the medics do all the time with diabetes so why shouldn't I <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="Daibell, post: 378839, member: 21149"] [b]Re: Overweight vs underweight... which is harder to deal wit[/b] Hi Kenny Interesting question. I guess much of my diabetes knowledge has been acquired over the 8 years since my diagnosis. I've been monitoring this form for several years now taking on-board an enormous amount of information and download and viewed many articles. So, I suffer an overload of sources, many in conflict, but have a background understanding across the diabetes spectrum. I'll see what I can dig out, but one 1998 research paper ([url=http://edrv.endojournals.org/content/19/4/491.long]http://edrv.endojournals.org/content/19/4/491.long[/url] - note you can download the article in pdf as well) discusses the fact that most T2s start by having insulin deficiency and then develop, additionally, insulin resistance if overweight. This is an interesting view; have a read and see what you think. So, I think you are right in assuming being overweight doesn't cause T2, but the paper suggests that if you are genetically pre-disposed to diabetes then being overweight will bring about insulin resistance following insulin deficiency. This is new information to me. There are several known causes of pancreatic failure to produce insulin e.g. islet cell anti-bodies as in T1 or Late onset T1. There are several identified antibodies such as GAD, II4 if I remember correctly and a few others. Pancreatitis is know problem. Viruses are known to cause problems and I'm sure there are many other genetically triggered causes. Now, taking myself as a sample of one (!) I had a C-peptide test done privately in 2012 and it showed I had virtually no insulin production. This confirmed my suspicions that the tablets I was on were a relative waste of time and I needed insulin which I now have. Now some would say the Gliclazide I was taking killed my pancreas but as it never helped much anyway there probably weren't too many islet cells left to damage in the first place. My private GAD test was negative but it often is and there are other antibodies not tested for. So, I'm one of that 20% sub-group who probably don't have insulin resistance because I'm not overweight; my acquired opinion. Anyway I will dig around a bit more and see what I can find to back-up my 'opinion'. As I said in my OP, I was generalising but that's what the medics do all the time with diabetes so why shouldn't I :) [/QUOTE]
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