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<blockquote data-quote="Bill_St" data-source="post: 1746401" data-attributes="member: 310899"><p>Again the CAA confirm it. “Patients who use insulin pumps should also be aware of the potential impact of changes in the cabin air pressure on insulin delivery. The reduction in ambient pressure on ascent may lead to a slight increase in delivery of insulin as a result of the formation / expansion of air bubbles, which may be sufficient to cause symptomatic hypoglycemia. A more severe impact could be seen in the (rare) event of sudden decompression of the cabin at altitude. A slight reduction in insulin delivery is also possible during descent.”</p><p>The pressure change can be equivalent to 8,000 ft (vertical!) in normal operations. Much more in the case of decompression. The longest chairlifts may approach 8,000 ft but in length, not in height.</p><p></p><p>And if you wish for medical evidence - <a href="http://care.diabetesjournals.org/content/34/9/1932" target="_blank">http://care.diabetesjournals.org/content/34/9/1932</a></p><p></p><p><strong>“CONCLUSIONS</strong> Atmospheric pressure reduction causes predictable, unintended insulin delivery in pumps by bubble formation and expansion of existing bubbles.</p><p></p><p>A 10-year-old girl with well-controlled type 1 diabetes managed with insulin pump therapy developed recurrent hypoglycemia 60 to 90 min after commencing commercial air travel. Upon direct inquiry, we are now aware of 50 children and adults using insulin pumps who experience this phenomenon.</p><p></p><p>In 1994, Aanderud et al. (<a href="http://care.diabetesjournals.org/content/34/9/1932#ref-1" target="_blank">1</a>) demonstrated that insulin pumps delivered “more insulin than the set rate during decompression.” At sea level, the ambient pressure is 760 mmHg (1 atmosphere). When commercial planes ascend to 40,000 feet, the cabin pressure decreases by 200 mmHg to 560 mmHg (cabin pressure equivalent of 8,000 feet) (<a href="http://care.diabetesjournals.org/content/34/9/1932#ref-2" target="_blank">2</a>). The objective of this study was to investigate the effects of pressure changes during airplane flight on insulin pump delivery.”</p><p></p><p>The study ends with recommendations that pumps should be disconnected before takeoff and landing.</p><p></p><p>“We recommend for flights:</p><p></p><ol> <li data-xf-list-type="ol">The cartridge should only contain 1.5 mL of insulin.<br /> <br /> </li> <li data-xf-list-type="ol">Disconnect the pump before takeoff.<br /> <br /> </li> <li data-xf-list-type="ol">At cruising altitude, take the cartridge out of the pump and remove any air bubbles before reconnecting.<br /> <br /> </li> <li data-xf-list-type="ol">After the airplane lands, disconnect the pump and prime the line with 2 units. Then reconnect the pump.<br /> <br /> </li> <li data-xf-list-type="ol">During flight emergencies involving cabin decompression, disconnect the insulin pump.<br /> </li> </ol><p>Insulin pumps deliver excess insulin as ambient pressure decreases, which may cause hypoglycemia. ”</p></blockquote><p></p>
[QUOTE="Bill_St, post: 1746401, member: 310899"] Again the CAA confirm it. “Patients who use insulin pumps should also be aware of the potential impact of changes in the cabin air pressure on insulin delivery. The reduction in ambient pressure on ascent may lead to a slight increase in delivery of insulin as a result of the formation / expansion of air bubbles, which may be sufficient to cause symptomatic hypoglycemia. A more severe impact could be seen in the (rare) event of sudden decompression of the cabin at altitude. A slight reduction in insulin delivery is also possible during descent.” The pressure change can be equivalent to 8,000 ft (vertical!) in normal operations. Much more in the case of decompression. The longest chairlifts may approach 8,000 ft but in length, not in height. And if you wish for medical evidence - [URL]http://care.diabetesjournals.org/content/34/9/1932[/URL] [B]“CONCLUSIONS[/B] Atmospheric pressure reduction causes predictable, unintended insulin delivery in pumps by bubble formation and expansion of existing bubbles. A 10-year-old girl with well-controlled type 1 diabetes managed with insulin pump therapy developed recurrent hypoglycemia 60 to 90 min after commencing commercial air travel. Upon direct inquiry, we are now aware of 50 children and adults using insulin pumps who experience this phenomenon. In 1994, Aanderud et al. ([URL='http://care.diabetesjournals.org/content/34/9/1932#ref-1']1[/URL]) demonstrated that insulin pumps delivered “more insulin than the set rate during decompression.” At sea level, the ambient pressure is 760 mmHg (1 atmosphere). When commercial planes ascend to 40,000 feet, the cabin pressure decreases by 200 mmHg to 560 mmHg (cabin pressure equivalent of 8,000 feet) ([URL='http://care.diabetesjournals.org/content/34/9/1932#ref-2']2[/URL]). The objective of this study was to investigate the effects of pressure changes during airplane flight on insulin pump delivery.” The study ends with recommendations that pumps should be disconnected before takeoff and landing. “We recommend for flights: [LIST=1] [*]The cartridge should only contain 1.5 mL of insulin. [*]Disconnect the pump before takeoff. [*]At cruising altitude, take the cartridge out of the pump and remove any air bubbles before reconnecting. [*]After the airplane lands, disconnect the pump and prime the line with 2 units. Then reconnect the pump. [*]During flight emergencies involving cabin decompression, disconnect the insulin pump. [/LIST] Insulin pumps deliver excess insulin as ambient pressure decreases, which may cause hypoglycemia. ” [/QUOTE]
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