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<blockquote data-quote="Stephen Lewis" data-source="post: 2044041" data-attributes="member: 479176"><p>The issue with all these drugs is that they do not do anything to improve DPN. They work on the brain to shut down pain receptors. Pregabalin is also used in the treatment of seizures. Reading GrannyAnnie's comments, it seems that she does not have, (and never had?) DPN but PN with a different cause. I have some symptoms of something nerve based in my very low back/hip area and think this may be related to DPN and the pancreas. I remember as a child that trapping nerves and/or blood vessels in the back of the leg and lumbar area on high, hard seats would cause severe pins and needles in my feet until I changed my sitting position. I did request information from a diabetic forum in Canada on any research into the possibility that diabetes is actually a neurological disorder. I also questioned that drug companies new this but providing an effective cure would affect their profits. I never did get an answer and then discovered that even with many well trained diabetes specialists the site seems to be financed by providers of blood testing equipment and drug companies. There may be no connection nevertheless I have recently decided to stop getting emails from that site. If anyone knows of research that proves why the pancreas stops working (apart from age, obesity etc.) I would be very interested to read it. Unfortunately this will not help those T1s where the cause seems more due to the endocrine/immune system.</p></blockquote><p></p>
[QUOTE="Stephen Lewis, post: 2044041, member: 479176"] The issue with all these drugs is that they do not do anything to improve DPN. They work on the brain to shut down pain receptors. Pregabalin is also used in the treatment of seizures. Reading GrannyAnnie's comments, it seems that she does not have, (and never had?) DPN but PN with a different cause. I have some symptoms of something nerve based in my very low back/hip area and think this may be related to DPN and the pancreas. I remember as a child that trapping nerves and/or blood vessels in the back of the leg and lumbar area on high, hard seats would cause severe pins and needles in my feet until I changed my sitting position. I did request information from a diabetic forum in Canada on any research into the possibility that diabetes is actually a neurological disorder. I also questioned that drug companies new this but providing an effective cure would affect their profits. I never did get an answer and then discovered that even with many well trained diabetes specialists the site seems to be financed by providers of blood testing equipment and drug companies. There may be no connection nevertheless I have recently decided to stop getting emails from that site. If anyone knows of research that proves why the pancreas stops working (apart from age, obesity etc.) I would be very interested to read it. Unfortunately this will not help those T1s where the cause seems more due to the endocrine/immune system. [/QUOTE]
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