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Physiology of insulin release - know your pancreas
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<blockquote data-quote="Bubbleblower" data-source="post: 2486384" data-attributes="member: 540059"><p><span style="font-size: 22px"> <span style="font-size: 15px">"Glucose-induced β-cell electrical activity, recorded with glass microelectrodes, is characterized by trains of fast action potentials (“spikes”). The membrane depolarizes before each train of spikes and then depolarizes. This pattern is termed a “burst.” There is a characteristic biphasic response to a square wave of 11.1 mM glucose. Pulses at higher glucose concentrations (22.2 mM or more) evoke transient, constant spike activity."</span></span></p><p></p><p><span style="font-size: 22px"><span style="font-size: 15px">Possibly this is why some schools say you should stay below 11.1 precisely (I always assumed that number came from 200mg/dl/18).</span></span></p><p></p><p><span style="font-size: 15px">The theory of beta cell de-differentiation may be mind bending but fact is high glucose changes the alpha to beta cells ratio, which may be why it is so important to give your overworked pancreas some rest. </span></p></blockquote><p></p>
[QUOTE="Bubbleblower, post: 2486384, member: 540059"] [SIZE=6] [SIZE=4]"Glucose-induced β-cell electrical activity, recorded with glass microelectrodes, is characterized by trains of fast action potentials (“spikes”). The membrane depolarizes before each train of spikes and then depolarizes. This pattern is termed a “burst.” There is a characteristic biphasic response to a square wave of 11.1 mM glucose. Pulses at higher glucose concentrations (22.2 mM or more) evoke transient, constant spike activity."[/SIZE][/SIZE] [SIZE=6][SIZE=4]Possibly this is why some schools say you should stay below 11.1 precisely (I always assumed that number came from 200mg/dl/18).[/SIZE][/SIZE] [SIZE=6][/SIZE] [SIZE=4]The theory of beta cell de-differentiation may be mind bending but fact is high glucose changes the alpha to beta cells ratio, which may be why it is so important to give your overworked pancreas some rest. [/SIZE] [/QUOTE]
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