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<blockquote data-quote="Allen50yearsT1" data-source="post: 2391907" data-attributes="member: 541736"><p>The express newspaper reported last week on a new pill for T1 treatment. It uses nanoparticles to protect the insulin through the stomach..</p><p><a href="https://www.express.co.uk/life-style/health/1422008/pill-vaccine-diabetes-type-one-jab-daily" target="_blank">https://www.express.co.uk/life-style/health/1422008/pill-vaccine-diabetes-type-one-jab-daily</a></p><p>If the link does not work here is the gist of the report, copied and pasted.</p><p></p><p><em><strong>Scientists have developed a groundbreaking capsule which, after being swallowed, automatically releases insulin when blood sugar levels get too high. It could replace traditional injections for type 1 sufferers, which can be difficult to self-administer and lead to people skipping doses.</strong></em></p><p></p><p><em><strong>The technology, developed by researchers from New York University Abu Dhabi, would help tackle the disease – the seventh leading cause of death worldwide.</strong></em></p><p></p><p><em><strong>Diabetes is characterised by inconsistent levels of the hormone insulin but developing a pill has been difficult as insulin is fragile.</strong></em></p><p></p><p><em><strong>It gets broken down by stomach enzymes before it reaches the bloodstream, where it is needed.</strong></em></p><p></p><p><em><strong>The challenge has been to find a way to package insulin so it can survive the trip through the stomach.</strong></em></p><p></p><p><em><strong>Researchers at NYU Abu Dhabi believe they’ve solved the problem by creating a framework of tiny organic particles which can resist the body’s efforts to digest them.</strong></em></p><p></p><p><em><strong>Amazingly, these capsules actually protect insulin from the harsh environment of the stomach to transport it safely to the bloodstream.</strong></em></p><p></p><p><em><strong>Once in the blood, the particles can automatically monitor a person’s insulin levels and only release the drug when it is needed.</strong></em></p><p></p><p><em><strong>Dr Farah Benyettou, a research chemist and lead author of the study, said: “Our work uses insulin-loaded nanoparticles which exhibit insulin protection in the stomach as well as a glucose-responsive release.</strong></em></p><p></p><p><em><strong>“This technology responds quickly to an elevation in blood sugar.</strong></em></p><p></p><p><em><strong>“But it would promptly shut off to prevent insulin overdose and will dramatically improve the wellbeing of diabetic patients.”</strong></em></p><p></p><p><em><strong>In tests on diabetic rats, the research team showed the pills brought the animals’ blood glucose levels back to normal within two hours of swallowing it.</strong></em></p><p></p><p><em><strong>Further work will now investigate implementing the technology with humans.</strong></em></p><p></p><p><em><strong>The study is published in the latest edition of the Royal Society of Chemistry journal, Chemical Science.</strong></em></p><p></p><p></p><p></p><p>It will of course take years for trials to be completed, but fingers crossed for us all, I doubt if I will survive to see it though</p></blockquote><p></p>
[QUOTE="Allen50yearsT1, post: 2391907, member: 541736"] The express newspaper reported last week on a new pill for T1 treatment. It uses nanoparticles to protect the insulin through the stomach.. [URL]https://www.express.co.uk/life-style/health/1422008/pill-vaccine-diabetes-type-one-jab-daily[/URL] If the link does not work here is the gist of the report, copied and pasted. [I][B]Scientists have developed a groundbreaking capsule which, after being swallowed, automatically releases insulin when blood sugar levels get too high. It could replace traditional injections for type 1 sufferers, which can be difficult to self-administer and lead to people skipping doses.[/B][/I] [I][B]The technology, developed by researchers from New York University Abu Dhabi, would help tackle the disease – the seventh leading cause of death worldwide.[/B][/I] [I][B]Diabetes is characterised by inconsistent levels of the hormone insulin but developing a pill has been difficult as insulin is fragile.[/B][/I] [I][B]It gets broken down by stomach enzymes before it reaches the bloodstream, where it is needed.[/B][/I] [I][B]The challenge has been to find a way to package insulin so it can survive the trip through the stomach.[/B][/I] [I][B]Researchers at NYU Abu Dhabi believe they’ve solved the problem by creating a framework of tiny organic particles which can resist the body’s efforts to digest them.[/B][/I] [I][B]Amazingly, these capsules actually protect insulin from the harsh environment of the stomach to transport it safely to the bloodstream.[/B][/I] [I][B]Once in the blood, the particles can automatically monitor a person’s insulin levels and only release the drug when it is needed.[/B][/I] [I][B]Dr Farah Benyettou, a research chemist and lead author of the study, said: “Our work uses insulin-loaded nanoparticles which exhibit insulin protection in the stomach as well as a glucose-responsive release.[/B][/I] [I][B]“This technology responds quickly to an elevation in blood sugar.[/B][/I] [I][B]“But it would promptly shut off to prevent insulin overdose and will dramatically improve the wellbeing of diabetic patients.”[/B][/I] [I][B]In tests on diabetic rats, the research team showed the pills brought the animals’ blood glucose levels back to normal within two hours of swallowing it.[/B][/I] [I][B]Further work will now investigate implementing the technology with humans.[/B][/I] [I][B]The study is published in the latest edition of the Royal Society of Chemistry journal, Chemical Science.[/B][/I] It will of course take years for trials to be completed, but fingers crossed for us all, I doubt if I will survive to see it though [/QUOTE]
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