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Diabetes Discussion
Type 1 Diabetes
Pramlintide (trade name --- Symlin)
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<blockquote data-quote="MarkMunday" data-source="post: 2293675" data-attributes="member: 525839"><p>Yes, I am interested in T1 experience with metformin because it seems like a no-brainer for T1s to me. T1s make too much glucagon because insulin is injected under the skin and doesn't come from the pancreas. In non-diabetics, the liver stops supplying glucose when it sees insulin, which comes through the portal vein from the pancreas next to it. T1 livers never get that message. So something that inhibits liver glucose would seem to make sense. But Metformin is not considered as T1 treatment for some reason. I tried it a while back and it seemed to reduce blood glucose. But the effect also seemed to be inconsistent, so I stopped it. I was eating high-carb back then. I want to try it again now that my control is much better.</p></blockquote><p></p>
[QUOTE="MarkMunday, post: 2293675, member: 525839"] Yes, I am interested in T1 experience with metformin because it seems like a no-brainer for T1s to me. T1s make too much glucagon because insulin is injected under the skin and doesn't come from the pancreas. In non-diabetics, the liver stops supplying glucose when it sees insulin, which comes through the portal vein from the pancreas next to it. T1 livers never get that message. So something that inhibits liver glucose would seem to make sense. But Metformin is not considered as T1 treatment for some reason. I tried it a while back and it seemed to reduce blood glucose. But the effect also seemed to be inconsistent, so I stopped it. I was eating high-carb back then. I want to try it again now that my control is much better. [/QUOTE]
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Pramlintide (trade name --- Symlin)
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