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Preparing for an OGTT
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<blockquote data-quote="Oldvatr" data-source="post: 2485216" data-attributes="member: 196898"><p>The technique is common to mice and other animal studies and works well in the lab, It is uncommon to use it in human studies. My searches only turned up 3 instances of human trials. Newcastle Diet, a chinese study and a study in America. Two of these studies reported problems with interpreting the results when used for T1D diagnosis and c-peptide testing, and i discovered a systemic error when Roy Taylor used it in the ND trials,</p><p></p><p>It seems that using a drip or infusion bypasses an essential part of the insulin response and that an important enzyme or two is not triggered (amylase?) so possibly introducing error especially when considering the first phase insulin response seen in humans, It may be responsible for some misdiagnosis in TOFI undividuals so the OGTT is perhaps a better test. C- peptide is normally assayed from a blood draw or urine test, so does not use this technique in humans.</p><p></p><p>Many of us here have an inherent mistrust of 'mice studies'. This is another aspect supporting that view,</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2485216, member: 196898"] The technique is common to mice and other animal studies and works well in the lab, It is uncommon to use it in human studies. My searches only turned up 3 instances of human trials. Newcastle Diet, a chinese study and a study in America. Two of these studies reported problems with interpreting the results when used for T1D diagnosis and c-peptide testing, and i discovered a systemic error when Roy Taylor used it in the ND trials, It seems that using a drip or infusion bypasses an essential part of the insulin response and that an important enzyme or two is not triggered (amylase?) so possibly introducing error especially when considering the first phase insulin response seen in humans, It may be responsible for some misdiagnosis in TOFI undividuals so the OGTT is perhaps a better test. C- peptide is normally assayed from a blood draw or urine test, so does not use this technique in humans. Many of us here have an inherent mistrust of 'mice studies'. This is another aspect supporting that view, [/QUOTE]
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