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Prof Taylor on the subject of Reversal.
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<blockquote data-quote="Oldvatr" data-source="post: 2204741" data-attributes="member: 196898"><p>I have said this before. The research that led to the Krebs Cycle (aka Citric Cycle) mapped out the pathways of glucose and energy in mitochondria in muscle tissue (not adipose cells) and established the hormone labelling and signalling that was involved. Now they did not manage to identify why these cells became resistant, but did manage to identify IR in the muscle cells as the first step to contracting diabetes. From this came the high glucose, the high insulin demand, and increasing need for insulin to overcome the resistance,</p><p></p><p>The work by Prof Taylor so far has identified an alternative pathway to diabetes via the adipocytes in the liver and pancreas. In my mind he did not address the questions of muscle IR, so has uncovered another aspect of T2D, (and a way of dealung with it). But if Muscle IR exists, then we do not yet have a cure IMHO. Both pathways will need to be repaired,</p><p></p><p>I strongly suspect that a breakdown in the hormone signalling system is to blame. It may be seed oils, it does not seem to be carbs on their own, and it seems not to be related to lipid levels either. There is a possible link to thyroid problems it seems and also to leaky gut syndrome, but we do not have the smoking gun yet,</p><p></p><p>Edit to add: here is a paper on muscle IR, It is not light reading though</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811436/#__ffn_sectitle" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811436/#__ffn_sectitle</a>.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2204741, member: 196898"] I have said this before. The research that led to the Krebs Cycle (aka Citric Cycle) mapped out the pathways of glucose and energy in mitochondria in muscle tissue (not adipose cells) and established the hormone labelling and signalling that was involved. Now they did not manage to identify why these cells became resistant, but did manage to identify IR in the muscle cells as the first step to contracting diabetes. From this came the high glucose, the high insulin demand, and increasing need for insulin to overcome the resistance, The work by Prof Taylor so far has identified an alternative pathway to diabetes via the adipocytes in the liver and pancreas. In my mind he did not address the questions of muscle IR, so has uncovered another aspect of T2D, (and a way of dealung with it). But if Muscle IR exists, then we do not yet have a cure IMHO. Both pathways will need to be repaired, I strongly suspect that a breakdown in the hormone signalling system is to blame. It may be seed oils, it does not seem to be carbs on their own, and it seems not to be related to lipid levels either. There is a possible link to thyroid problems it seems and also to leaky gut syndrome, but we do not have the smoking gun yet, Edit to add: here is a paper on muscle IR, It is not light reading though [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811436/#__ffn_sectitle[/URL]. [/QUOTE]
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