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Progressed onto Insulin - is it reversible?
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<blockquote data-quote="stevew242" data-source="post: 2129528" data-attributes="member: 514165"><p>Thanks for your reply.</p><p></p><p>At the moment, the focus has been on getting blood sugar down and no blood tests beyond the basics have been done. They did test for the antibodies the first time around and I think other tests (C-peptide) suggested I was still producing insulin. The weight loss the first time was also preceeded by a lot of weight gain over many years. None of this means I haven't developed T1 of course and it's worth finding out. My questions were not so much focussing on the past but looking for hope that if the issue still is resistance (or has been) whether I can recover some pancreas function. The research at Roy Taylor has done at Newcastle University seems to suggest that around 10 years appears to be a cut-off point, I guess I was hoping to hear of other cases where people had found themselves able to reverse T2 even after a significant period.</p><p></p><p>I don't take metformin at the moment, but that's largely because when I was discharged I was doing well and managing without. I also wonder whether it really does improve insulin resistance or just inhibit GNG, which isn't necessarily a bad thing but doesn't seem like solving the underlying problem. One question I've not had an answer to is whether metformin would slow down the fat clearance of the liver in a carbohydrate constrained environment - i.e. is execessive GNG a way of the liver getting rid of excess fat? I don't know whether my liver is fatty, but given my recent eating/drinking habits I wouldn't be surprised. I've generally resisted the temptation to medicate my blood sugar down to normal as studies such as ACCORD suggest it doesn't really help. I am, of course, at the same time full of **** as I have been ignoring what I know I should have been doing.</p><p></p><p>I've asked my GP about getting some blood tests done whilst I wait for a referral to the consultants to see if I can get some picture of what is happening and whether I've done any damage. Knowing whether it is late onset T1 will help. I have a lot of first degree relatives who are T2, many of whom you wouldn't expect from external appearances as they're slim so it looks like insulin resistance runs in the family. But as you say, this doesn't mean I'm not at the same time T1.</p><p></p><p>I take the point about monitoring and have been doing it pretty intensively and watching responses to food / dosages etc. One thing I want to avoid is acting like some diabetic friends whom I know who spend their lives eating what they want and injecting accordingly - whilst their initial problem was T1, some of them are now struggling with retinopathy, angina and all sorts after years of blood sugar going all over the place. The diabetes nurses seem keen to get me to focus on getting rid of ketones and have encouraged me to think differently about carbs, which I feel cautious about as I don't want to inject any more insulin than is absolutely necessary given that I probably am highly resistant anyway.</p></blockquote><p></p>
[QUOTE="stevew242, post: 2129528, member: 514165"] Thanks for your reply. At the moment, the focus has been on getting blood sugar down and no blood tests beyond the basics have been done. They did test for the antibodies the first time around and I think other tests (C-peptide) suggested I was still producing insulin. The weight loss the first time was also preceeded by a lot of weight gain over many years. None of this means I haven't developed T1 of course and it's worth finding out. My questions were not so much focussing on the past but looking for hope that if the issue still is resistance (or has been) whether I can recover some pancreas function. The research at Roy Taylor has done at Newcastle University seems to suggest that around 10 years appears to be a cut-off point, I guess I was hoping to hear of other cases where people had found themselves able to reverse T2 even after a significant period. I don't take metformin at the moment, but that's largely because when I was discharged I was doing well and managing without. I also wonder whether it really does improve insulin resistance or just inhibit GNG, which isn't necessarily a bad thing but doesn't seem like solving the underlying problem. One question I've not had an answer to is whether metformin would slow down the fat clearance of the liver in a carbohydrate constrained environment - i.e. is execessive GNG a way of the liver getting rid of excess fat? I don't know whether my liver is fatty, but given my recent eating/drinking habits I wouldn't be surprised. I've generally resisted the temptation to medicate my blood sugar down to normal as studies such as ACCORD suggest it doesn't really help. I am, of course, at the same time full of **** as I have been ignoring what I know I should have been doing. I've asked my GP about getting some blood tests done whilst I wait for a referral to the consultants to see if I can get some picture of what is happening and whether I've done any damage. Knowing whether it is late onset T1 will help. I have a lot of first degree relatives who are T2, many of whom you wouldn't expect from external appearances as they're slim so it looks like insulin resistance runs in the family. But as you say, this doesn't mean I'm not at the same time T1. I take the point about monitoring and have been doing it pretty intensively and watching responses to food / dosages etc. One thing I want to avoid is acting like some diabetic friends whom I know who spend their lives eating what they want and injecting accordingly - whilst their initial problem was T1, some of them are now struggling with retinopathy, angina and all sorts after years of blood sugar going all over the place. The diabetes nurses seem keen to get me to focus on getting rid of ketones and have encouraged me to think differently about carbs, which I feel cautious about as I don't want to inject any more insulin than is absolutely necessary given that I probably am highly resistant anyway. [/QUOTE]
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