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<blockquote data-quote="Dark Horse" data-source="post: 2431229" data-attributes="member: 52527"><p>Advice from NICE is that the dose of acarbose should be titrated upwards to reduce gastrointestinal side-effects:-</p><p></p><p style="margin-left: 20px"><em>By mouth</em></p> <ul style="margin-left: 20px"> <li data-xf-list-type="ul"><em>For Adult<br /> Initially 50 mg daily, then increased to 50 mg 3 times a day for 6–8 weeks, then increased if necessary to 100 mg 3 times a day (max. per dose 200 mg 3 times a day). <br /> <a href="https://bnf.nice.org.uk/drug/acarbose.html#cautions" target="_blank">https://bnf.nice.org.uk/drug/acarbose.html#cautions</a></em></li> </ul><p>This suggests that the initial dose may not be high enough to have a significant effect but a dose that is high enough may cause unwanted gastro-intestinal side-effects.</p></blockquote><p></p>
[QUOTE="Dark Horse, post: 2431229, member: 52527"] Advice from NICE is that the dose of acarbose should be titrated upwards to reduce gastrointestinal side-effects:- [INDENT][I]By mouth[/I] [LIST] [*][I]For Adult Initially 50 mg daily, then increased to 50 mg 3 times a day for 6–8 weeks, then increased if necessary to 100 mg 3 times a day (max. per dose 200 mg 3 times a day). [URL]https://bnf.nice.org.uk/drug/acarbose.html#cautions[/URL][/I] [/LIST][/INDENT] This suggests that the initial dose may not be high enough to have a significant effect but a dose that is high enough may cause unwanted gastro-intestinal side-effects. [/QUOTE]
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