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Raised blood sugar

C

celast

Well-Known Member
Messages
157
Location
wilmslow cheshire
Type of diabetes
Treatment type
Diet only
When its said that raised blood sugar over a number of years can lead to organ damage etc. do they mean your blood sugar has to raised all the time for a year or too or does it mean if occasionally it go's up to ten or eleven when tested after two hours of eating
 
Basically there isn't much evidence and what there is seems to point to HbA1c and average glucose levels being the most important. Some have suggested that higher post prandial readings are associated with a higher risk of CVD.
There is evidence that long/medium term variability isn't good (ie yo-yoing between periods of good and poor control) and may be a risk factor in the development of microvascular problems.
(one of the reasons there isn't much evidence is that it would require lots of daily testing and records over many years to produce good evidence.
The best evidence is from the DCCT, a type 1 trial that with it's follow up lasted for 20 years but they only looked at a sample day every 3 months)

However, you are unlikely to get low HbA1cs if you have frequent highs.
an association between increasing short-term glycaemic variability and an additional risk of micro-or macrovascular complications has so far proved to be elusive. Retrospective data analyses of the Diabetes Control and Complications Trial (DCCT) have shown little signal that within-day variability is important in the development of microvascular complications .
However, this study was not originally designed to address this question.
Although postprandial hyperglycaemia (a subset of glucose variability) is generally regarded as a risk marker for cardiovascular disease [5], the only prospective study to specifically assess whether reducing within-day glycaemia might influence cardiovascular events has been unable show any benefit [6].
E. S. Kilpatrick (*)
Department of Clinical Biochemistry, Hull Royal Infirmary,
5)Contributions of basal and post-prandial hyperglycaemia to micro- and macrovascular complications in people with type 2 diabetes
http://www.ncbi.nlm.nih.gov/pubmed/16004665
Diabetologia (2012) 55:2089–2091
DOI 10.1007/s00125-012-2610-5
Click to expand...
The above paper reviews some recent research on HbA1c variability.
This one is from 2009 and reviews the evidence on glucose variability
http://edrv.endojournals.org/content/31/2/171.full
 
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