Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Food and Nutrition
Low-carb Diet Forum
Raised GGT levels, Diabetes and Non-alcoholic Fatty liver Disease (NAFLD):trail of low carb diet
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="Southport GP" data-source="post: 901616" data-attributes="member: 74036"><p>AT LAST!! after so much work over three years our article is to be published this September in Diabesity in Practice. the Editor has agreed for you all to have a pre-publication summary. this is part of my efforts to get recognition that the low carb diet is a valid choice -not just for folk with diabetes but also for some of those with liver problems. Also that this is a diet that works on the longer term -not just a few weeks. <strong>The summary</strong>: </p><p></p><p>Abnormal liver function tests are often attributed to excessive alcohol consumption and/or medication without further investigation. However they may be secondary to non-alcoholic fatty liver disease (NAFLD).<strong> NAFLD is now</strong> <strong>prevalent in 20-30% of adults in the Western World.</strong> Considering the increased cardiovascular and metabolic risk of NAFLD, identification and effective risk factor management of these patients is critical.</p><p></p><p><strong><em>Background</em></strong>Excess dietary glucose leads progressively to hepatocyte triglyceride accumulation (non-alcoholic fatty liver disease-NAFLD), insulin resistance and T2DM. Considering the increased cardiovascular risks of NAFLD and T2DM, effective risk-factor management of these patients is critical. Weight loss can improve abnormal liver biochemistry, the histological progression of NAFLD, and diabetic control. <strong>However, the most effective diet remains controversial.</strong></p><p></p><p><strong><em>Aim </em></strong>We implemented a low-carbohydrate (CHO) diet in a primary health setting, assessing the effect on serum GGT, HbA1c levels (as proxies for suspected NAFLD and diabetic control), and weight.</p><p></p><p><strong><em>Design</em></strong>69 patients with a mean GGT of 77 iu/L (NR 0-50) and an average BMI of 34.4Kg/m2 were recruited opportunistically and advised on reducing total glucose intake (including starch), while increasing intake of natural fats, vegetables and protein.</p><p></p><p><strong><em>Method</em></strong> Baseline blood samples were assessed for GGT levels, lipid profile, and HbA1c. Anthropometrics were assessed and repeated at monthly intervals. The patients were provided monthly support by their general practitioner or practice nurse, either individually or as a group.</p><p></p><p><strong><em>Results</em></strong>After an average of 13 months on a low-CHO diet there was a 46% mean reduction in GGT of 29.9 iu/L (95% CI= -43.7, -16.2; <em>P</em><0.001), accompanied by average reductions in weight [-8.8Kg (95% CI= -10.0, -7.5; <em>P</em><0.001)],and HbA1c [10.0mmol/mol (95% CI= -13.9, -6.2; <em>P</em><0.001)].</p><p></p><p><strong><em>Conclusions</em></strong> We provide evidence that low-carbohydrate, dietary management of patients with T2DM and/or suspected NAFLD in primary care is feasible and improves abnormal liver biochemistry and other cardio-metabolic risk factors. This raises the question as to whether dietary carbohydrate plays a role in the etiology of diabetes and NAFLD, as well as obesity. Over the study period and given a choice not a single patient opted to start antidiabetic medication, losing weight instead. This helps explain why our practice is the only one in the Southport and Formby CCG to have static diabetes drug costs for three years running.</p></blockquote><p></p>
[QUOTE="Southport GP, post: 901616, member: 74036"] AT LAST!! after so much work over three years our article is to be published this September in Diabesity in Practice. the Editor has agreed for you all to have a pre-publication summary. this is part of my efforts to get recognition that the low carb diet is a valid choice -not just for folk with diabetes but also for some of those with liver problems. Also that this is a diet that works on the longer term -not just a few weeks. [B]The summary[/B]: Abnormal liver function tests are often attributed to excessive alcohol consumption and/or medication without further investigation. However they may be secondary to non-alcoholic fatty liver disease (NAFLD).[B] NAFLD is now[/B] [B]prevalent in 20-30% of adults in the Western World.[/B] Considering the increased cardiovascular and metabolic risk of NAFLD, identification and effective risk factor management of these patients is critical. [B][I]Background[/I][/B]Excess dietary glucose leads progressively to hepatocyte triglyceride accumulation (non-alcoholic fatty liver disease-NAFLD), insulin resistance and T2DM. Considering the increased cardiovascular risks of NAFLD and T2DM, effective risk-factor management of these patients is critical. Weight loss can improve abnormal liver biochemistry, the histological progression of NAFLD, and diabetic control. [B]However, the most effective diet remains controversial.[/B] [B][I]Aim [/I][/B]We implemented a low-carbohydrate (CHO) diet in a primary health setting, assessing the effect on serum GGT, HbA1c levels (as proxies for suspected NAFLD and diabetic control), and weight. [B][I]Design[/I][/B]69 patients with a mean GGT of 77 iu/L (NR 0-50) and an average BMI of 34.4Kg/m2 were recruited opportunistically and advised on reducing total glucose intake (including starch), while increasing intake of natural fats, vegetables and protein. [B][I]Method[/I][/B] Baseline blood samples were assessed for GGT levels, lipid profile, and HbA1c. Anthropometrics were assessed and repeated at monthly intervals. The patients were provided monthly support by their general practitioner or practice nurse, either individually or as a group. [B][I]Results[/I][/B]After an average of 13 months on a low-CHO diet there was a 46% mean reduction in GGT of 29.9 iu/L (95% CI= -43.7, -16.2; [I]P[/I]<0.001), accompanied by average reductions in weight [-8.8Kg (95% CI= -10.0, -7.5; [I]P[/I]<0.001)],and HbA1c [10.0mmol/mol (95% CI= -13.9, -6.2; [I]P[/I]<0.001)]. [B][I]Conclusions[/I][/B] We provide evidence that low-carbohydrate, dietary management of patients with T2DM and/or suspected NAFLD in primary care is feasible and improves abnormal liver biochemistry and other cardio-metabolic risk factors. This raises the question as to whether dietary carbohydrate plays a role in the etiology of diabetes and NAFLD, as well as obesity. Over the study period and given a choice not a single patient opted to start antidiabetic medication, losing weight instead. This helps explain why our practice is the only one in the Southport and Formby CCG to have static diabetes drug costs for three years running. [/QUOTE]
Verification
Post Reply
Home
Forums
Food and Nutrition
Low-carb Diet Forum
Raised GGT levels, Diabetes and Non-alcoholic Fatty liver Disease (NAFLD):trail of low carb diet
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…