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Rarest of rare allergy to Insulin
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<blockquote data-quote="phoenix" data-source="post: 313381" data-attributes="member: 12578"><p>Your post sent me on a search so I've put in my steps.</p><p>I found these papers.</p><p>Successful management of allergy to the insulin </p><p>excipient metacresol in a child with type 1 diabetes: </p><p>a case report. This said as you have been told said that there are no available insulins without m cresol.</p><p><a href="http://www.jmedicalcasereports.com/content/pdf/1752-1947-6-263.pdf" target="_blank">http://www.jmedicalcasereports.com/cont ... -6-263.pdf</a></p><p></p><p>I </p><p>Successful desensitization with human insulin in a patient with an </p><p>insulin allergy and hypersensitivity to protamine:</p><p><a href="http://www.biomedcentral.com/content/pdf/1752-1947-2-283.pdf" target="_blank">http://www.biomedcentral.com/content/pd ... -2-283.pdf</a></p><p> This one had a list of insulins and ingredients.</p><p>There were 2 that didn't mention m. cresol. </p><p>The first Berlinsulin H normal© on further research seems to contain it.</p><p>The second Insulin Novo semilente </p><p>This has been discontinued but I found a pet diabetes site which suggested that lente, semi lente and ultra lente insulins don't (can't) contain m cresol.</p><p><a href="http://petdiabetes.wikia.com/wiki/Preservatives" target="_blank">http://petdiabetes.wikia.com/wiki/Preservatives</a></p><p></p><p>It also seems that Novo Monotard also dosesn't (didn't) have any: This seems to have been withdrawn in most places but I found mention of it on an Indian site but that maybe out of date.</p><p></p><p>I then went to the Wockhardt site</p><p><a href="http://www.wockhardt.co.uk/products/productdetail.asp?productid=358" target="_blank">http://www.wockhardt.co.uk/products/pro ... ductid=358</a></p><p>I found 2 insulins with no mention of m.cresol. (the others did)</p><p></p><p>Hypurin® Bovine Lente 100 IU/ml injection </p><p>excipients:</p><p> </p><p>Sodium chloride</p><p>Sodium acetate</p><p>Methylparahydroxybenzoate</p><p>Zinc oxide</p><p>Water for injections</p><p>Hydrochloric acid</p><p>Sodium hydroxide</p><p></p><p>Hypurin® Bovine Protamine Zinc Insulin</p><p>excipients</p><p> </p><p>Protamine sulphate</p><p>Zinc chloride</p><p>Glycerol</p><p>Sodium phosphate</p><p>Phenol</p><p>Water for injections</p><p>I wouldn't take this as gospel but it would be worth contacting the company.</p></blockquote><p></p>
[QUOTE="phoenix, post: 313381, member: 12578"] Your post sent me on a search so I've put in my steps. I found these papers. Successful management of allergy to the insulin excipient metacresol in a child with type 1 diabetes: a case report. This said as you have been told said that there are no available insulins without m cresol. [url=http://www.jmedicalcasereports.com/content/pdf/1752-1947-6-263.pdf]http://www.jmedicalcasereports.com/cont ... -6-263.pdf[/url] I Successful desensitization with human insulin in a patient with an insulin allergy and hypersensitivity to protamine: [url=http://www.biomedcentral.com/content/pdf/1752-1947-2-283.pdf]http://www.biomedcentral.com/content/pd ... -2-283.pdf[/url] This one had a list of insulins and ingredients. There were 2 that didn't mention m. cresol. The first Berlinsulin H normal© on further research seems to contain it. The second Insulin Novo semilente This has been discontinued but I found a pet diabetes site which suggested that lente, semi lente and ultra lente insulins don't (can't) contain m cresol. [url=http://petdiabetes.wikia.com/wiki/Preservatives]http://petdiabetes.wikia.com/wiki/Preservatives[/url] It also seems that Novo Monotard also dosesn't (didn't) have any: This seems to have been withdrawn in most places but I found mention of it on an Indian site but that maybe out of date. I then went to the Wockhardt site [url=http://www.wockhardt.co.uk/products/productdetail.asp?productid=358]http://www.wockhardt.co.uk/products/pro ... ductid=358[/url] I found 2 insulins with no mention of m.cresol. (the others did) Hypurin® Bovine Lente 100 IU/ml injection excipients: Sodium chloride Sodium acetate Methylparahydroxybenzoate Zinc oxide Water for injections Hydrochloric acid Sodium hydroxide Hypurin® Bovine Protamine Zinc Insulin excipients Protamine sulphate Zinc chloride Glycerol Sodium phosphate Phenol Water for injections I wouldn't take this as gospel but it would be worth contacting the company. [/QUOTE]
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