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Message: <blockquote data-quote="Melgar" data-source="post: 2707709" data-attributes="member: 520626">Totally agree.I believe my own first phase insulin release  is very weak to non existent . I gather our beta cell function starts to decrease significantly a few years before any significant blood sugar problems show up. Is the first phase compromised in the majority of those suffering from RH? My own blood sugar starts to rise around 30 to 40 minutes after the first mouthful. I rarely detect any rise on my CGM before, which I’m assuming I would see It, no matter how subtle.  My understanding is that your first phase insulin release is activated from a constant reserve of insulin, within 10 minutes after our beta cells detect a rise in blood sugar. There is only a small amount of insulin in that reserve. The second phase is then activated,the beta cells have to produce that insulin, and then the insulin is  continually  produced until homeostasis is achieved. Such a fine intricate system. I read somewhere that beta cells are 10 x more sensitive to blood sugar than sny other cell in our body. They are intricately connected to a bunch of blood vessels with the pancreas. It blows my mind. There is a lot to go wrong !</blockquote>

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