Researchers uncover link between preventing type 1 diabetes and gut bacteria

[DCUK NewsBot]

Gut bacteria may play a role in the prevention of type 1 diabetes, according to new research. The study, conducted by researchers at the National Institute of Health and Medical Research (INSERM) in France, found that cathelicidins, a group of antimicrobial peptides, were not produced in the pancreatic beta cells of mice with diabetes. Mice without diabetes, however, do produce cathelicidins. "Injecting cathelicidins inhibits the development of pancreatic inflammation and, as such, suppressed the development of autoimmune disease in these mice," said Julien Diana, a researcher at INSERM. Cathelicidins are produced thanks to short-chain fatty acids in the gut bacteria. To further test their findings, the researchers moved gut bacteria of non-diabetic mice into the diabetic mice. The fatty acids began to produce cathelicidin in the diabetic mice. Previous research has suggested that the mechanisms work similarly in humans. In theory, then, the findings could provide new and effective treatments for type 1 diabetes. However, the research needs to be tested further; it is currently at a preliminary stage. "This research is further evidence of the undeniable role microbiota plays in autoimmune diseases, particularly in controlling the development of autoimmune diabetes," said the authors. The findings were published in Cell: Immunity.

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[ButtterflyLady]

Interesting research, however animal studies are not as reliable as human trials. We are still a long way off having a treatment that can be used to prevent T1 diabetes in some people. It would be good if this study helps researchers to get to the human trials stage.

 

[phoenix]

Interesting .
I wonder if the mice that were 'cured' actually had a similar gut environment to people with T1.
There is a relatively common genetic mutation associated with T1 that results in some types of bacteria not being able to survivefor long in the gut. I don't know if this is one of them . The mutation is beneficial in one way, people who have it are very resistant to some viruses (eg noro virus) and HIV isn't so progressive in people with mutation .It's not good in that it doesn't allow some friendly bacteria to grow so if you have other T1 'genes' then it contributes to the risk of developing it. ( similarly with people genetically disposed to Crohn's and Coeliac)

http://www.diabetes.co.uk/forum/xfa-blogs/phoenix.12578/