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<blockquote data-quote="LittleGreyCat" data-source="post: 2089849" data-attributes="member: 6467"><p>Came across this after following a link to local research projects from another thread.</p><p></p><p>Wikipedia link <a href="https://en.wikipedia.org/wiki/Semaglutide" target="_blank">https://en.wikipedia.org/wiki/Semaglutide</a></p><p></p><p>Initially there seem to be some good things about it.</p><p></p><ul> <li data-xf-list-type="ul">GLP-1 look alike with minor modification to prevent enzymatic removal from the blood stream.</li> <li data-xf-list-type="ul">Lasts about a week between injections.</li> <li data-xf-list-type="ul">Increases insulin secretion.</li> <li data-xf-list-type="ul">Can encourage regeneration of Beta cells!</li> <li data-xf-list-type="ul">Inhibits glucagon production (which increase BG levels as an opposite to insulin which lowers them).</li> </ul><p></p><p>Hmmm.....any side effects?</p><p></p><p>"Semaglutide has minor adverse effects. Nausea, vomiting, diarrhea, abdominal pain, and constipation are usually experienced.<a href="https://en.wikipedia.org/wiki/Semaglutide#cite_note-20" target="_blank">[20]</a> In patients with heart (<a href="https://en.wikipedia.org/wiki/Cardiovascular_disease" target="_blank">cardiovascular</a>) problem, it causes retinal (eye) damage (<a href="https://en.wikipedia.org/wiki/Retinopathy" target="_blank">retinopathy</a>)."</p><p></p><p>I was considering it no worse than Metformin until I read the bit about retinopathy.</p><p></p><p>Anyone been using this long term?</p><p></p><p>At the moment (from using my first Freestyle Libre) I am wondering if I am over producing glucagon.</p><p></p><p>However I have read that stimulating the pancreas can lead to increased loss of beta cells over time.</p><p></p><p>So possibly not a magic cure.</p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 2089849, member: 6467"] Came across this after following a link to local research projects from another thread. Wikipedia link [URL]https://en.wikipedia.org/wiki/Semaglutide[/URL] Initially there seem to be some good things about it. [LIST] [*]GLP-1 look alike with minor modification to prevent enzymatic removal from the blood stream. [*]Lasts about a week between injections. [*]Increases insulin secretion. [*]Can encourage regeneration of Beta cells! [*]Inhibits glucagon production (which increase BG levels as an opposite to insulin which lowers them). [/LIST] Hmmm.....any side effects? "Semaglutide has minor adverse effects. Nausea, vomiting, diarrhea, abdominal pain, and constipation are usually experienced.[URL='https://en.wikipedia.org/wiki/Semaglutide#cite_note-20'][20][/URL] In patients with heart ([URL='https://en.wikipedia.org/wiki/Cardiovascular_disease']cardiovascular[/URL]) problem, it causes retinal (eye) damage ([URL='https://en.wikipedia.org/wiki/Retinopathy']retinopathy[/URL])." I was considering it no worse than Metformin until I read the bit about retinopathy. Anyone been using this long term? At the moment (from using my first Freestyle Libre) I am wondering if I am over producing glucagon. However I have read that stimulating the pancreas can lead to increased loss of beta cells over time. So possibly not a magic cure. [/QUOTE]
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