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<blockquote data-quote="LittleGreyCat" data-source="post: 2091128" data-attributes="member: 6467"><p>I note, however, that Liraglutide is not a preferred option.</p><p><a href="https://en.wikipedia.org/wiki/Liraglutide" target="_blank">https://en.wikipedia.org/wiki/Liraglutide</a> as the usual (sometimes reliable) source.</p><p>"In diabetes it is a less preferred agent.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a><a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-NICE2011-2" target="_blank">[2]</a> Its effects on long term health outcomes like <a href="https://en.wikipedia.org/wiki/Heart_disease" target="_blank">heart disease</a> and life expectancy are unclear.".</p><p></p><p>Also, "Common side effects include <a href="https://en.wikipedia.org/wiki/Low_blood_sugar" target="_blank">low blood sugar</a>, nausea, dizziness, abdominal pain, and pain at the site of injection.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a> Other serious side effects may include <a href="https://en.wikipedia.org/wiki/Medullary_thyroid_cancer" target="_blank">medullary thyroid cancer</a>, <a href="https://en.wikipedia.org/wiki/Angioedema" target="_blank">angioedema</a>, <a href="https://en.wikipedia.org/wiki/Pancreatitis" target="_blank">pancreatitis</a>, <a href="https://en.wikipedia.org/wiki/Gallbladder_disease" target="_blank">gallbladder disease</a>, and <a href="https://en.wikipedia.org/wiki/Kidney_problems" target="_blank">kidney problems</a>.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a> Use in <a href="https://en.wikipedia.org/wiki/Pregnancy" target="_blank">pregnancy</a> and <a href="https://en.wikipedia.org/wiki/Breastfeeding" target="_blank">breastfeeding</a> is of unclear safety.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a> Liraglutide is a <a href="https://en.wikipedia.org/wiki/Glucagon-like_peptide-1_receptor_agonist" target="_blank">glucagon-like peptide-1 receptor agonist</a>(GLP-1 receptor agonist) also known as <a href="https://en.wikipedia.org/wiki/Incretin" target="_blank">incretin</a><a href="https://en.wikipedia.org/wiki/Mimetics" target="_blank">mimetics</a>.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a> It works by increasing insulin release from the <a href="https://en.wikipedia.org/wiki/Pancreas" target="_blank">pancreas</a> and decreases excessive <a href="https://en.wikipedia.org/wiki/Glucagon" target="_blank">glucagon</a> release.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a>".</p><p></p><p>The side effects look a bit scary, and worse than those listed for Semaglutide. In fact Semaglutide is supposed to improve kidney function instead of potentially causing problems.</p><p></p><p>Finally "In diabetes it is a less preferred agent.<a href="https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1" target="_blank">[1]</a> It may be used in those in who <a href="https://en.wikipedia.org/wiki/Metformin" target="_blank">metformin</a> and another <a href="https://en.wikipedia.org/wiki/Antidiabetic_medication" target="_blank">antidiabetic medication</a> such as a <a href="https://en.wikipedia.org/wiki/Sulfonylurea" target="_blank">sulfonylurea</a> are not sufficient.".</p><p></p><p>Perhaps wrongly, I was looking for a form of medication which helped balance my insulin and glucagon production (as suggested by my current Libre readings) instead of just kicking my pancreas to produce more insulin (with consequent hypo risks) and the possibility of having to notify DVLA if I have uncontrolled hypos.</p><p>I note from my Libre (although it is still reading lower than finger pricks) that I do have lows in BG around midnight some nights.</p><p></p><p>However I think that most of the "glutides" seem to be 3rd line options if Metformin + Sulphonylureas combined don't work.</p><p></p><p>I was hoping that Semaglutide might be an option which didn't rely on Sulphonylureas failing to work adequately.</p><p></p><p>Transitioning from Metformin and exercise to more aggressive medication seems to be a minefield.</p><p></p><p>[USER=345386]@DCUKMod[/USER] as well. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 2091128, member: 6467"] I note, however, that Liraglutide is not a preferred option. [URL]https://en.wikipedia.org/wiki/Liraglutide[/URL] as the usual (sometimes reliable) source. "In diabetes it is a less preferred agent.[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL][URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-NICE2011-2'][2][/URL] Its effects on long term health outcomes like [URL='https://en.wikipedia.org/wiki/Heart_disease']heart disease[/URL] and life expectancy are unclear.". Also, "Common side effects include [URL='https://en.wikipedia.org/wiki/Low_blood_sugar']low blood sugar[/URL], nausea, dizziness, abdominal pain, and pain at the site of injection.[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL] Other serious side effects may include [URL='https://en.wikipedia.org/wiki/Medullary_thyroid_cancer']medullary thyroid cancer[/URL], [URL='https://en.wikipedia.org/wiki/Angioedema']angioedema[/URL], [URL='https://en.wikipedia.org/wiki/Pancreatitis']pancreatitis[/URL], [URL='https://en.wikipedia.org/wiki/Gallbladder_disease']gallbladder disease[/URL], and [URL='https://en.wikipedia.org/wiki/Kidney_problems']kidney problems[/URL].[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL] Use in [URL='https://en.wikipedia.org/wiki/Pregnancy']pregnancy[/URL] and [URL='https://en.wikipedia.org/wiki/Breastfeeding']breastfeeding[/URL] is of unclear safety.[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL] Liraglutide is a [URL='https://en.wikipedia.org/wiki/Glucagon-like_peptide-1_receptor_agonist']glucagon-like peptide-1 receptor agonist[/URL](GLP-1 receptor agonist) also known as [URL='https://en.wikipedia.org/wiki/Incretin']incretin[/URL][URL='https://en.wikipedia.org/wiki/Mimetics']mimetics[/URL].[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL] It works by increasing insulin release from the [URL='https://en.wikipedia.org/wiki/Pancreas']pancreas[/URL] and decreases excessive [URL='https://en.wikipedia.org/wiki/Glucagon']glucagon[/URL] release.[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL]". The side effects look a bit scary, and worse than those listed for Semaglutide. In fact Semaglutide is supposed to improve kidney function instead of potentially causing problems. Finally "In diabetes it is a less preferred agent.[URL='https://en.wikipedia.org/wiki/Liraglutide#cite_note-AHFS2019-1'][1][/URL] It may be used in those in who [URL='https://en.wikipedia.org/wiki/Metformin']metformin[/URL] and another [URL='https://en.wikipedia.org/wiki/Antidiabetic_medication']antidiabetic medication[/URL] such as a [URL='https://en.wikipedia.org/wiki/Sulfonylurea']sulfonylurea[/URL] are not sufficient.". Perhaps wrongly, I was looking for a form of medication which helped balance my insulin and glucagon production (as suggested by my current Libre readings) instead of just kicking my pancreas to produce more insulin (with consequent hypo risks) and the possibility of having to notify DVLA if I have uncontrolled hypos. I note from my Libre (although it is still reading lower than finger pricks) that I do have lows in BG around midnight some nights. However I think that most of the "glutides" seem to be 3rd line options if Metformin + Sulphonylureas combined don't work. I was hoping that Semaglutide might be an option which didn't rely on Sulphonylureas failing to work adequately. Transitioning from Metformin and exercise to more aggressive medication seems to be a minefield. [USER=345386]@DCUKMod[/USER] as well. :-) [/QUOTE]
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